Anti-hypertensive and endothelia protective effects of Fufang Qima capsule(复方芪麻胶囊) on primary hypertension via adiponectin/adenosine monophosphate activated protein kinase pathway  

作　　者：ZHAO Zhiyue SHI Zhenyu ZHANG Zhenzhen LI Yinghong ZENG Xiaohui CHEN Yuxing YAO Nan ZHOU Min SU Hui WANG Qinghai JIN LiLi 

机构地区：[1]Department of Cardiovascular,The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine(Guangdong Second Traditional Chinese Medicine Hospital),Guangzhou 510095,China [2]Department of the Electrocardiogram,The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine(Guangdong Second Traditional Chinese Medicine Hospital),Guangzhou 510095,China [3]Department of Science and Education,The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine(Guangdong Second Traditional Chinese Medicine Hospital),Guangzhou 510095,China [4]Pharmacological Laboratory,The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine(Guangdong Second Traditional Chinese Medicine Hospital),Guangzhou 510095,China [5]Department of Emergency,The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine(Guangdong Second Traditional Chinese Medicine Hospital),Guangzhou 510095,China

出　　处：《Journal of Traditional Chinese Medicine》2021年第6期919-926,共8页中医杂志（英文版）

基　　金：Supported by the Project From the Department of Guangdong Science and Technology(Establishment and Promotion of TCM Prevention and Treatment Network of Hypertension,No.2017A020213010);Guangdong TCM Science and Technology Innovation Platform Project(Research on Prevention and Treatment of Cardio-cerebrovascular Diseases with TCM,No.Guangdong Traditional Chinese Medicine Letter[2018]No.6);China Administration of Traditional Chinese Medicine the Old Famous Experts Inheritance Studio Construction project(China TCM File[2016]No.42)。

摘　　要：OBJECTIVE:To investigate the potential mechanism of the vascular remodeling effect and provide additional information about anti-hypertension activity of Fufang Qima capsule(复方芪麻胶囊,QM).METHODS:Spontaneous hypertensive rats(SHRs)were used to study the underlying mechanism of the anti-hypertension activity of QM.In this study,SHRs were randomly divided into 5 groups:model group,Telmisartan group(7.2 mg/kg,p.o.),and three QM groups(0.9298,1.8596,and 3.7192 g/kg,p.o.).Wistar Kyoto rats(WKY)were used as normal control group.Blood pressure(BP),aorta,perivascular adipose tissue(PVAT)histology were investigated to evaluate the effect of QM.Nitric oxide(NO)and endothelial nitric oxide synthase(eNOS)phosphorylation were measured.Adiponectin(APN)secretion,as well as APN signal pathway proteins including APN,adiponectin receptors(R1 and R2)and adenosine 5’-monophosphate-activated protein kinase(AMPK)were all analyzed.RESULTS:QM significantly reduced BP and ameliorated the vascular pathological change,i.e.intima media thicken and collagen fiber hyperplasia.Meanwhile,QM increased concentration of NO and the phosphorylation of eNOS in the aorta.The anti-hypertensive and endothelia-protective effect of QM could be attributed to activating APN/AMPK pathway by up-regulating the expression of APN in PVAT and APN Receptor 2,AMPKαand phosphorylated AMPKαin the aorta.CONCLUSION:The QM alleviation effect mechanism for primary hypertension was via modulating the APN/AMPK signal pathway.

关 键 词：hypertension ADIPONECTIN AMP-activated protein kinases nitric oxide synthase typeⅢ Fufang Qima capsule 

分 类 号：R285.5[医药卫生—中药学]