不同剂量多巴胺受体激动剂在帕金森病治疗中的应用效果  

Application effect of different doses of Dopamine agonists in the treatment of Parkinson′s disease

作　　者：安娜[1] AN Na(The Second Ward,Anshan Cancer Hospital,Liaoning Province,Anshan114034,China)

机构地区：[1]辽宁省鞍山市肿瘤医院内二病房,辽宁鞍山114034

出　　处：《中国当代医药》2022年第1期101-103,共3页China Modern Medicine

摘　　要：目的探讨不同剂量多巴胺受体激动剂在帕金森病治疗中的应用效果。方法选取2017年9月至2019年9月鞍山市肿瘤医院收治的66例帕金森患者作为研究对象,按照动态随机分组法分将其为对照组与观察组,每组各33例。对照组患者采用小剂量多巴胺受体激动剂(盐酸普拉克索片)治疗,观察组患者采用大剂量盐酸普拉克索片治疗。比较两组患者的帕金森病评定量表(UPDRSDI)评分以及简明健康测量量表(SF-36)评分。结果治疗第4、8、12周,观察组患者的UPDRSDI评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的SF-36评分高于对照组,差异有统计学意义(P<0.05)。结论多巴胺受体激动剂在帕金森病治疗中的效果显著,而剂量的不同,效果也会不同,大剂量的使用会提升临床治疗效果,在临床的实际运用当中,应当结合患者的实际病情做出评估。Objective To investigate the application effect of different doses of Dopamine receptor agonists in the treatment of Parkinson′s disease.Methods A total of 66 patients with Parkinson′s disease admitted to Anshan cancer hospital from September 2017 to September 2019 were selected as the research objects and divided into the control group and the observation group according to the dynamic random grouping method,with 33 cases in each group.The control group was treated with low-dose Dopamine receptor agonist(Pramipexole Hydrochloride Tablets)and the observation group was treated with high-dose Pramipexole Hydrochloride Tablets.The results of unified Parkinson′s disease rating scale(UPDRSDI)and the medical outcomes study 36-item short-form health survey(SF-36)scores were compared between the two groups.Results At the 4^(th),8^(th) and 12^(th) week of treatment,UPDRSDI scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the SF-36 score of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Dopamine agonists have a significant effect in the treatment of Parkinson′s disease,and the effect varies with the dose.The use of large doses will improve the clinical treatment effect,so the clinical application should be evaluated based on the actual condition of patients.

关 键 词：多巴胺受体激动剂 帕金森 剂量 疗效 生活质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]