无托槽隐形矫治器对牙周炎正畸疼痛及IL-6、MMP-8、TNF-α水平的影响  

Effects of bracketless invisible appliance and straight wire appliance on pain and level of gingival crevicular fluid and serum IL-6,MMP-8 and TNF-αin patients with periodontitis undergoing orthodontics

作　　者：曲晓东[1] 冯志才[2] 崔明 QU Xiao-dong;FENG Zhi-cai;CUI Ming(Department of Stomatology,Liuzhou People’s Hospital,Guangxi Liuzhou 545000,China;Department of Orthodontics,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Guangzhou 510055,China;Department of Cardiology,Liuzhou People’s Hospital,Guangxi Liuzhou 545000,China)

机构地区：[1]柳州市人民医院口腔科,广西柳州545000 [2]中山大学附属光华口腔医学院正畸科,广东广州510055 [3]柳州市人民医院心内科,广西柳州545000

出　　处：《临床口腔医学杂志》2021年第12期749-753,共5页Journal of Clinical Stomatology

基　　金：广西壮族自治区卫生健康委员会科研课题(编号Z20200109)。

摘　　要：目的:探究无托槽隐形矫治器对牙周炎正畸患者疼痛、龈沟液及血清中白细胞介素-6(IL-6)、人基质金属蛋白酶-8(MMP-8)、肿瘤坏死因子-α(TNF-α)水平的影响。方法:将我院60例牙周炎正畸患者随机分为观察组与对照组各30例;两组均给予牙周炎基础治疗后,对照组直丝弓矫治器治疗,观察组无托槽隐形矫治器治疗。比较两组临床疗效、疼痛程度、血清及龈沟液炎性因子水平及牙周指标变化。结果:观察组总有效率为93.33%,对照组为73.33%,差异有统计学意义(P<0.05)。观察组治疗后6 h、3 d、7 d的疼痛程度均明显低于对照组(P<0.05)。治疗6个月后,两组血清及龈沟液中IL-6、MMP-8、TNF-α水平较治疗前均上升,但观察组低于对照组(P<0.05);观察组PLI、PD较治疗前上升,而对照组PLI、SBI、GI、PD、CAL较治疗前均明显上升,观察组明显低于对照组(P<0.05)。结论:无托槽隐形矫治器较直丝弓矫治器治疗牙周炎正畸疗效更佳,治疗后炎性因子及疼痛程度显著控制,有利于患者牙周状态的改善。Objective:To explore the effects of bracketless invisible appliance and straight wire appliance on pain and levels of gingival crevicular fluid and serum interleukin-6(IL-6),human matrix metalloproteinase-8(MMP-8)and tumor necrosis factor-α(TNF-α)in patients with periodontitis undergoing orthodontics.Methods:A total of 60 orthodontic patients with periodontitis were selected as the study subjects,were divided into observation group and control group with 30 cases in each group.Both groups of patients were given basic treatment for periodontitis,and control group was treated with straight wire appliance,observation group was given bracketless invisible appliance.The clinical efficacy after the end of treatment,pain level at different time points,and levels of inflammatory factors in serum and gingival crevicular fluid and periodontal status indicators before and after 6 months of treatment were compared.Results:The total effective rate was 93.33%in observation group and was 73.33%in control group(P<0.05).The pain level in observation group was significantly lower than that in control group at 6 h,3 d and 7 d after treatment(P<0.05).After 6 months of treatment,the levels of IL-6,MMP-8 and TNF-αin serum and gingival crevicular fluid of the two groups were significantly higher than those before treatment,but the levels in observation group were significantly lower(P<0.05).After 6 months of treatment,the PLI and PD in observation group were significantly higher than those before treatment(P<0.05).The PLI,SBI,GI,PD and CAL in control group were significantly higher than those before treatment,and the indexes in observation group were significantly lower(P<0.05).Conclusion:Bracketless invisible appliance has better efficacy than straight wire appliance in the treatment of periodontitis.It can significantly control the inflammatory factors and pain level after treatment,and it is beneficial to the improvement of periodontal status of patients.

关 键 词：无托槽隐形矫治器 牙周炎 疼痛 人基质金属蛋白酶-8 肿瘤坏死因子-α 

分 类 号：R783.5[医药卫生—口腔医学] R781.4[医药卫生—临床医学]