长期服用抗精神病药物的精神分裂症患者肝胆彩色多普勒超声异常改变情况及影响因素分析  

Abnormal Changes and Influencing Factors of Liver and Gallbladder Color Doppler Ultrasound in Schizophrenic Patients Taking Antipsychotics for A Long Time

作　　者：欧阳永红 董月英[1] 刘海波[1] 陈建 占家铣 OUYANG Yonghong;DONG Yueying;LIU Haibo;CHEN Jian;ZHAN Jiaxian(The Third Hospital of Quanzhou City,Quanzhou 362121,China;不详)

机构地区：[1]泉州市第三医院,福建泉州362121 [2]福建省福州神经精神病防治院

出　　处：《中外医学研究》2021年第35期77-79,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究长期服用抗精神病药物的精神分裂症患者肝胆彩色多普勒超声异常改变情况,并分析影响患者肝胆超声异常的相关因素。方法:回顾性分析2017年10月-2020年12月笔者所在医院182例精神分裂症患者的临床资料。所有患者进行肝胆彩色多普勒超声检查,按照患者的肝胆彩超结果分为超声正常组和超声异常组。比较两组患者年龄、性别、药物类型、用药时间、联合用药等方面的差异性,并采用Logistic回归模型对各项因素进行回归分析。结果:182例长期用药的精神分裂症患者中,超声正常患者100例,占54.95%,超声异常者82例,占45.05%。两组年龄、药物类型、用药时间、联合用药方面比较,差异均有统计学意义(P<0.05)。Logistic回归分析显示,年龄≥70岁、使用典型抗精神病药物、联合用药是导致长期用药的精神分裂症患者肝胆彩超检查结果异常的独立危险因素(P<0.05)。结论:年龄≥70岁、使用典型抗精神病药物、联合用药会导致长期服用抗精神病药物的精神分裂症患者出现肝胆损伤,应当根据患者的需求合理选择治疗方案,提高用药安全性。Objective:To explore the abnormal changes of liver and gallbladder color Doppler ultrasound in schizophrenic patients taking antipsychotics for a long time,and analyze the related factors affecting the abnormal liver and gallbladder ultrasound.Method:The clinical data of 182 schizophrenic patients in authors’ hospital from October 2017 to December 2020 were retrospectively analyzed.All patients underwent liver-gallbladder color doppler ultrasonography,and they were divided into normal ultrasound group and abnormal ultrasound group according to the results of liver-gallbladder color doppler ultrasonography.The age,gender,drug type,duration of medication and combination medication were compared between two groups,and the Logistic regression model was used for regression analysis of each factor.Result:Among 182 schizophrenic patients with long-term medication,100 patients had normal ultrasound,accounting for 54.95%,and 82 patients had abnormal ultrasound,accounting for 45.05%.There were statistically significant differences in age,drug type,medication duration and drug combination between two groups (P<0.05).Logistic regression analysis showed that age ≥70 years old,use of typical antipsychotics and combined medication were independent risk factors for abnormal results of color Doppler ultrasonography in schizophrenic patients with long-term medication (P<0.05).Conclusion:The age ≥70 years old,the use of typical antipsychotics and combined medication will lead to liver and gallbladder injury in schizophrenic patients taking antipsychotics for a long time.The treatment scheme should be reasonably selected according to the needs of patients to improve the safety of medication.

关 键 词：精神分裂症 长期用药 彩色多普勒超声 肝胆功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]