血清补体C_(3)和C_(4)检测对自身免疫性肝炎患者病情评估的价值  

Value of Serum Complement C_(3) and C_(4) Detection in Patients with Autoimmune Hepatitis

作　　者：宋林 SONG Lin(Dalian Public Health Clinical Center,Dalian Sixth People's Hospital,Dalian 116031,China)

机构地区：[1]大连市公共卫生临床中心,大连市第六人民医院,辽宁大连116031

出　　处：《中国医药指南》2022年第1期131-133,共3页Guide of China Medicine

摘　　要：目的研究在自身免疫性肝炎患者病情评估中应用血清补体的价值。方法将2017年2月至2019年2月到本院治疗的72例自身免疫性肝炎患者作为试验对象,按发病情况划分为缓解期和活动期,各36例。采用全自动生物化学分析仪对两组患者的肝功能生化指标进行检测,应用透射比浊法依次检测外周血内的补体C_(3)、C_(4)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)及肝脏穿刺病理组织情况。比较缓解期和活动期各项指标水平,以Spearman相关分析方式分析血清补体C_(3)、C_(4)水平和肝功能生化指标的相关性,分析活动期血清补体C_(3)、C_(4)水平与病理组织相关性。结果活动期患者谷氨酸转移酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、碱性磷酸酶(ALP)、γ-谷氨酰酸酞酶(GGT)、IgG均比缓解期患者高(P<0.05);活动期患者血清补体C_(3)、C_(4)表达水平则比缓解期患者低(P<0.05);患者的AST、TBIL、DBIL水平随着C_(3)表达水平的升高而降低,差异有统计学意义(P<0.05)。C_(3)表达水平与ALT、GGT、ALP水平不相关性(P>0.05);C_(4)表达水平与ALT、AST、TBIL、DBIL、GGT、ALP水平均不相关性也不具备统计学意义(P>0.05)。17例活动期患者C_(4)表达水平随着组织学活动指数(HAI)降低而升高(P<0.05),呈负相关关系。结论自身免疫性肝炎活动期患者血清补体C_(3)、C_(4)均呈下降趋势,利用其辅助诊断可使后期治疗更加简便。Objective To study the value and role of serum complement in the evaluation of autoimmune hepatitis patients.Methods A total of 72 patients with autoimmune hepatitis who came to our hospital for treatment from February 2017 to February 2019 were taken as experimental subjects.According to the incidence,the remission period and the active period were divided into 36 cases.Fully automatic biochemical analyzer was used to detect the liver function biochemical indicators of the two groups of patients,and the turbidimetric method was used to detect complement C_(3),C_(4),immunoglobulin G(IgG),and immunoglobulin A(IgA),immunoglobulin M(IgM)and pathological tissues of liver puncture.Compare the levels of various indicators in the remission period and the active period,analyze the correlation between serum complement C_(3) and C_(4) levels and biochemical indicators of liver function by Spearman rank correlation analysis,and analyze the correlation between serum complement C_(3) and C_(4) levels and pathological tissue in the active period.Results:Active patients with glutamate transferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),direct bilirubin(DBIL),alkaline phosphatase(ALP),γ-glutamate GGT and IgG are both higher than those in remission patients(P<0.05);serum complement C_(3) and C_(4) expression levels in active patients are lower than those in remission patients(P<0.05);patients'AST,TBIL,and DBIL levels increase with C_(3) expression levels reduced,the difference was statistically significant(P<0.05).The correlation between C_(3) expression level and ALT,GGT,and ALP levels is not statistically significant(P>0.05);the correlation between C_(4) expression level and ALT,AST,TBIL,DBIL,GGT,and ALP levels is not significant(P>0.05).The expression level of C_(4) in 17 active patients increased with the decrease of histological activity index(HAI)(P<0.05),showing a negative correlation.Conclusion The serum complement C_(3) and C_(4) of patients with active autoimmune hepatitis show a downward trend,which

关 键 词：免疫性肝炎 补体 病情评估 组织学活动指数 

分 类 号：R575.1[医药卫生—消化系统]