肠道微生物、昼夜节律对代谢的影响在非酒精性脂肪肝中的作用  

Effects of intestinal microbiota and circadian rhythm on metabolism in nonalcoholic fatty liver disease

作　　者：徐小杰 周燕[2] 李汛[3,4,5,6] XU Xiaojie;ZHOU Yan;LI Xun(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,the First Hospital of Lanzhou University,Lanzhou 730000,China;Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province,Lanzhou 730000,China;Cancer Prevention and Treatment Center of Lanzhou University School of Medicine,Lanzhou 730000,China;Institute of Hepatopancreatobiliary Surgery of Gansu Province,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院药剂科,兰州730000 [3]兰州大学第一医院普外科,兰州730000 [4]甘肃省生物治疗与再生医学重点实验室,兰州730000 [5]兰州大学医学院肿瘤防治中心,兰州730000 [6]甘肃省肝胆胰外科研究所,兰州730000

出　　处：《生命的化学》2021年第11期2434-2444,共11页Chemistry of Life

基　　金：甘肃省科技重大专项(1602FKDA001);甘肃省科技计划项目(18JR2TA018);中央高校基本科研业务费(lzujbky-2019-kb21,lzujbky-2020-kb22)。

摘　　要：非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)是目前最常见的肝脏慢性疾病,以胰岛素抵抗和脂肪蓄积为主要特征的代谢紊乱是其最主要表现。肠道微生物和昼夜节律在调控机体代谢稳态中均扮演了重要角色,且二者还可以相互影响,共同参与机体代谢过程的多个方面,这与NAFLD的发生发展密切相关。此外,靶向肠道微生物、昼夜节律来诊断和治疗NAFLD也显示出一定的临床运用前景。为此,本文综述了肠道微生物、昼夜节律对代谢的影响及其在NAFLD中的作用,为NAFLD的发病机制和诊治提供新的视角。Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease at present.Metabolic disorders mainly characterized by insulin resistance and fat accumulation are the most important features of NAFLD.Both intestinal microbiota and circadian rhythms play important roles in the regulation of metabolic homeostasis of the body,and they can interact with each other and jointly participate in many aspects of the metabolic process of the body,which is closely related to the occurrence and development of NAFLD.In addition,there is a clinical prospect for the diagnosis and treatment of NAFLD by targeting intestinal microbiota and circadian rhythm.In this review,we will summarize the effects of intestinal microbiota and circadian rhythm on metabolism and their roles in NAFLD.This will provide a new perspective for the pathogenesis of NAFLD,as well as for its diagnosis and treatment.

关 键 词：肠道微生物 昼夜节律 生物钟 非酒精性脂肪肝 代谢 

分 类 号：R575.5[医药卫生—消化系统]