神经酰胺激酶(CerK)催化反应的肿瘤生物学意义  

Ceramide kinase(CerK)-catalyzed biological reaction in tumor cells

作　　者：余明皓 齐隽[1] YU Ming-Hao;QI Jun(Department of Urology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院泌尿外科,上海200092

出　　处：《生命科学》2021年第11期1409-1417,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81970657)。

摘　　要：神经酰胺激酶(ceramide kinase,CerK)是唯一已知的在哺乳动物细胞中催化神经酰胺(ceramide,Cer)磷酸化为1-磷酸神经酰胺(ceramide-1-phosphate,C1P)的脂蛋白酶。作为该酶促反应底物的Cer在神经鞘脂代谢和信号转导途径中起着中心介质的作用,调节许多基础的细胞反应;而C1P作为该酶促反应产物,同样是与细胞功能和命运密切相关的生物活性脂质。现有研究表明,CerK、Cer及C1P均参与调控肿瘤细胞增殖、存活、凋亡与迁移/转移,与肿瘤发生和发展密切相关,是抗肿瘤治疗的潜在靶点。Ceramide kinase(CerK)is the only known lipid protein enzyme that catalyzes the phosphorylation of ceramide(Cer)to ceramide-1-phosphate(C1 P)in mammalian cells.Ceramide,as the substrate of the enzyme reaction,plays a central role in sphingolipid metabolism and signal transduction pathways,regulating many basic cellular responses.C1 P,as the product of the enzyme reaction,is also a bioactive lipid closely related to cell function and fate.Current researches have shown that CerK,Cer and C1 P can regulate the proliferation,survival,apoptosis and migration/metastasis of tumor cells,which are closely related to the occurrence and development of tumor,and can be used as potential targets for anti-tumor therapy.

关 键 词：神经酰胺激酶 神经酰胺 1-磷酸神经酰胺 神经鞘脂信号通路 抗肿瘤药物 

分 类 号：R730.2[医药卫生—肿瘤]