The novel function of citronellal for antidiabetic cardiomyopathy  

作　　者：Yue Qiu Liuwei Meng Chunyan Chao Ling Wang Yang Wang Tianheng Liu Yutian Fu Yue Li Yuting Song Yaqi Guo Qianqian Niu Jie Zhang Yaling Yin Peng Li 

机构地区：[1]College of Pharmacy,Xinxiang Medical University,Xinxiang 450003,China [2]Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention,Xinxiang 450003,China [3]Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development,Xinxiang 450003,China [4]HuangHuai University,Zhumadian 463000,China [5]Department of Pharmacy,Puyang County People's Hospital,Puyang 457100,China [6]The Third Affiliated Hospital,Xinxiang Medical University,Xinxiang 450003,China [7]School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 450003,China

出　　处：《Acta Biochimica et Biophysica Sinica》2021年第12期1731-1735,共5页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(Nos.81874312 and U1804197);Research Foundation of Henan Province(Nos.202300410308,2018GGJS102,18HASTIT047,and ZD2020006 and 219906);Research Foundation of Xinxiang Medical University(Nos.XYBSKYZZ201626,XYBSKYZZ505319,YJSCX202041Y,and KYCX2020-38).

摘　　要：Diabetic cardiomyopathy(DCM),a leading cause of morbidity and mortality,is a diabetes-related complication characterized by myocardial fibrosis,left ventricular(LV)hypertrophy,and compromised cardiac function[1].Citronellal(CT;Fig.1A)is a monoter-pene aldehyde primarily produced by the secondary metabolism of plants.It is a non-racemic mixture of R and S enantiomers obtained from bergamot and citronella oil[2].

关 键 词：CARDIOMYOPATHY METABOLISM MORTALITY 

分 类 号：R542.2[医药卫生—心血管疾病] R587.1[医药卫生—内科学]