Anisotanols A—D,Four Norsesquiterpenoids with an Unprece-dented Sesquiterpenoid Skeleton from Anisodus tanguticus  

作　　者：Hao-Yu Zhao Qin-Mei Zhou Huan Zhu Fei Zhou Chun-Wang Meng Hong-Zhen Shu Zhao-Hua Liu Cheng Peng Liang Xiong 

机构地区：[1]School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,China [2]State Key Laboratory of Southwestern Chinese Medicine Resources,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,China [3]Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,China [4]Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,China [5]Chengdu No.l Pharmaceutical Co.,Ltd.,Chengdu,Sichuan 610031,China

出　　处：《Chinese Journal of Chemistry》2021年第12期3375-3380,共6页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(NNSFC,Grant Nos.82022072 and 81891012);the Fok Ying Tung Education Foundation(Grant No.171037);the Sichuan Science and Technology Program(Grant No.2018JZ0081);the"Xinglin Scholar"Plan of Chengdu University of TCM(Grant Nos.YXRC2018005,BSH2018009,and QNXZ2019030).

摘　　要：Anisotanols A—D(1-4),four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system,were obtained from Anisodus tanguticus.Their structures were elucidated by comprehensive spectroscopic techniques,and the absolute configurations were confirmed via ECD calculations and single-crystal X-ray diffractions.A putative biosynthetic pathway for these compounds was proposed.Biological evaluation disclosed that compound 3 showed anti-angiogenic activity by inhibiting the viability,migration,and tube formation in HUVECs.

关 键 词：Anisodus tanguticus TERPENOIDS Structure elucidation Anisotane-type ANGIOGENESIS 

分 类 号：O62[理学—有机化学]