乳腺癌患者血常规及PLR、NLR、LMR特征分析  

Analysis of blood routine test and PLR,NLR,LMR in breast cancer patients

作　　者：王坤英 张蓬杰[2] 苏兵[3] 王慧英 董新华 杨秋霞 WANG Kunying;ZHANG Pengjie;SU Bing;WANG Huiying;DONG Xinhua;YANG Qiuxia(Nephropathy Laboratory,Shanxi Second People's Hospital,Taiyuan,Shanxi 030012,China;Nephropathy Hemodialysis Center,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi 710068,China;Disease Surveillance Center,Taiyuan Center for Disease Control and Prevention,Taiyuan,Shanxi 030012,China;Department of Clinical Laboratory,Shanxi Second People's Hospital,Taiyuan,Shanxi 030012,China)

机构地区：[1]山西省第二人民医院肾病实验室,山西太原030012 [2]陕西省人民医院肾病血透中心,陕西西安710068 [3]太原市疾病预防控制中心疾病监测中心,山西太原030012 [4]山西省第二人民医院检验科,山西太原030012

出　　处：《检验医学与临床》2022年第1期84-89,共6页Laboratory Medicine and Clinic

摘　　要：目的探讨乳腺癌患者、健康对照者血常规及血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)差异,为乳腺癌患者危险分层与分类管理提供参考依据。方法选取2015-2019年初诊的174例乳腺癌女性患者(乳腺癌组)与同期181例体检健康女性(健康对照组)作为研究对象,比较两组血常规、PLR、NLR、LMR,以及不同病理特征乳腺癌患者血常规、PLR、NLR、LMR水平。结果乳腺癌组白细胞计数(WBC)、血小板计数(PLT)、中性粒细胞绝对值(NEU)、单核细胞绝对值(MONO)、血小板压积(PCT)、大型血小板比率(P-LCR)均高于健康对照组,淋巴细胞绝对值(LYM)、嗜酸性粒细胞绝对值(EO)低于健康对照组,差异均有统计学意义(P<0.05)。乳腺癌组PLR、NLR均高于健康对照组,LMR低于健康对照组,差异均有统计学意义(P<0.05),且NLR对于乳腺癌的早期诊断效能要优于PLR、LMR。30~<45岁乳腺癌组WBC、MONO、NEU、PLR、NLR均显著高于健康对照组,LMR显著低于健康对照组,差异均有统计学意义(P<0.05)。45~<60岁乳腺癌组WBC、PLT、MONO、NEU、PCT、PLR、NLR均显著高于健康对照组,LYM、EO、LMR显著低于健康对照组,差异均有统计学意义(P<0.05)。≥60岁乳腺癌组WBC、MONO、NEU、NLR均显著高于健康对照组,LMR显著低于健康对照组,差异均有统计学意义(P<0.05);肿瘤最大径>2 cm患者NLR显著低于肿瘤最大径≤2 cm患者,差异有统计学意义(P<0.05)。结论乳腺癌与血常规、PLR、NLR、LMR密切相关,并在不同年龄段、肿瘤最大径间有不同的表现。血常规可为乳腺癌患者进行危险分层与精准分类管理提供参考依据,应引起重视。Objective To provide reference for risk stratification and classification management of breast cancer patients,blood routine and platelet-lymphocyte ratio(PLR),neutrophil-lymphocytes ratio(NLR)and lymphocyte-monocyte ratio(LMR)were compared between the breast cancer patients and the healthy controls.Methods From January 2015 to December 2019,174 female breast cancer patients(breast cancer group)and 181 healthy women(healthy control group)were selected as the research subjects.The blood routine,PLR,NLR and LMR of the two groups were compared,and stratified for different age groups.The changes of blood routine,PLR,NLR and LMR in breast cancer patients with different pathological characteristics were analyzed.Results WBC,PLT,neutrophil(NEU),monocyte(MONO),thrombocytocrit(PCT)and large platelet ratio(P-LCR)in breast cancer group were significantly higher than those in healthy control group,and lymphocyte(LYM)and eosinophil(EO)in breast cancer group were significantly lower than those in healthy control group,the differences were statistically significant(P<0.05).PLR and NLR of breast cancer group were significantly higher than that of healthy control group,while LMR was significantly lower than that in healthy control group,the differences were statistically significant(P<0.05),and NLR was superior to PLR and LMR in the early diagnosis of breast cancer patients.For patients who were 30-<45 years in breast cancer group,the WBC,MONO,NEU,PLR,NLR were significantly higher than that of healthy con-trol group,but LMR was significantly lower than that of healthy control group,the differences were statisti-cally significant(P<0.05).For patients who were 45-<60 years in breast cancer group,the WBC,PLT,MONO,NEU,PCT,PLR,NLR were significantly higher than that of healthy control group,LYM,EO,LMR significantly lower than that of healthy control group,the differences were statistically significant(P<0.05).For patients who were≥60 years in breast cancer group,the WBC,MONO,NEU,NLR were significantly higher than that of healthy con

关 键 词：乳腺癌 血常规 血小板/淋巴细胞比值 中性粒细胞/淋巴细胞比值 淋巴细胞/单核细胞比值 

分 类 号：R739.91[医药卫生—肿瘤]