酒精经下丘脑POMC/AgRP神经元致能量失衡机制研究进展  

Research progress on the mechanism of induced energy imbalance caused by alcohol via hypothalamic POMC/AgRP neurons

作　　者：杜琴[1] 严宗逊[1] 宗海红(综述) 李敬东(审校)[2] DU Qin;YAN Zong-xun;ZONG Hai-hong;LI Jing-dong(Department of Endocrinology,Affiliated Hospital of North Sichuan Medical College,Nanchang 631000,Sichuan,China;Institute of Hepatobiliary,Enteropancreatic Diseases,Affiliated Hospital of North Sichuan Medical College,Nanchang 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院内分泌科,南充637000 [2]川北医学院肝胆肠胰疾病研究所,南充637000

出　　处：《医学研究生学报》2021年第12期1320-1325,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81370531)。

摘　　要：弓形的黑皮质素系统在控制体内能量稳态功能中起主要作用,其由表达促黑素皮质素(pro-opiomelanocoryin/P0MC)的神经元和表达神经肽Y/刺鼠相关肽(neuropeptide Y/agouti-related peptide/NPY/AgRP)的神经元组成。酒精可直接或间接影响P0MC生物合成,POMC/AgKP通过衍生的多种肽信号来调节食物消耗和能量平衡。文章就POMC/AgRP在大脑中的表达、功能、影响POMC/AgRP神经元的因素及酒精经下丘脑POMC/AgRP神经元调控能量代谢的机理研究进展进行综述。The arcuate melanocortin system plays a major role in controlling energy homeostatic function of the body,which is composed of neurons expressing proopiomelanocortin/POMC and neurons expressing neuropeptide Y/Agoutirelated peptide/NPY/AgRP.Alcohol can affect POMC biosynthesis directly or indirectly,POMC/AgRP regulates food consumption and energy balance through a variety of derived peptide signals.This paper reviews the expression and function of POMC/AgRP in the brain,the factors affecting POMC/AgRP neurons and the mechanism of alcohol regulating energy metabolism through hypothalamus POMC/AgRP neu-rons.

关 键 词：酒精 POMC/AgRP神经元 瘦素 胰岛素抵抗 

分 类 号：R741[医药卫生—神经病学与精神病学]