纤维乳管镜检查与液基细胞学检查对具有乳头溢液表现的乳腺导管内增生性病变的临床诊断价值  

The value of firberoptic ductoscopic examination and liquid-based cytologic test in clinical diagnosis of intraductal proliferative lesions of breast with nipple discharge

作　　者：王丽丽[1] 黄晖[2] 徐曙光[1] 许焕玲[2] 岑红艺[2] WANG Li-li;HUANG Hui;XU Shu-guang(Department of Pathology,Jiangmen Maternal and Child Health Hospital,Jiangmen 529000,China)

机构地区：[1]江门市妇幼保健院病理科,529000 [2]江门市妇幼保健院乳腺科,529000

出　　处：《中国实用医药》2021年第36期66-69,共4页China Practical Medicine

基　　金：江门市医疗卫生科技计划项目“乳管镜灌洗液液基细胞学检查与脱落细胞学检查的病理对比分析”(项目编号:2019D010)。

摘　　要：目的探究纤维乳管镜检查与液基细胞学检查对具有乳头溢液表现的乳腺导管内增生性病变的临床诊断价值。方法100例具有病理性乳头溢液的患者为研究对象,均进行纤维乳管镜检查、液基细胞学检查和手术标本活检检查。对比纤维乳管镜检查、液基细胞学检查、纤维乳管镜联合液基细胞学检查、手术标本活检检查的结果。结果手术标本活检检查结果显示:乳头状肿瘤70例,导管上皮增生6例,乳腺癌4例,乳腺其他良性病变20例。纤维乳管镜检查结果显示:乳头状肿瘤55例,导管上皮增生3例,乳腺癌2例,乳腺其他良性病变40例。液基细胞学检查结果显示:乳头状肿瘤53例,导管上皮增生2例,乳腺癌2例,乳腺其他良性病变43例。纤维乳管镜联合液基细胞学检查结果显示:乳头状肿瘤65例,导管上皮增生5例,乳腺癌3例,乳腺其他良性病变27例。纤维乳管镜诊断乳腺导管内增生性病变(乳头状肿瘤、导管上皮增生及乳腺癌)的符合率为75.00%(60/80)。液基细胞学检查诊断乳腺导管内增生性病变(乳头状肿瘤、导管上皮增生及乳腺癌)的符合率为71.25%(57/80)。纤维乳管镜联合液基细胞学检查诊断乳腺导管内增生性病变(乳头状肿瘤、导管上皮增生及乳腺癌)的符合率为91.25%(73/80)。纤维乳管镜联合液基细胞学检查的诊断符合率高于纤维乳管镜检查、液基细胞学检查,差异具有统计学意义(χ^(2)=7.530、10.503,P<0.05)。结论纤维乳管镜与液基细胞学联合检查对乳腺导管内增生性病变的诊断符合率较高,临床应用价值较高。Objective To evaluate the diagnostic value of firberoptic ductoscopic examination and liquid-based cytologic test in the clinical diagnosis of intraductal proliferative lesions of breast with nipple discharge.Methods 100 patients with pathological nipple discharge were selected as study subjects.All patients received firberoptic ductoscopic examination,liquid-based cytologic test and biopsy of surgical specimens.The results of firberoptic ductoscopic examination,liquid-based cytologic test,firberoptic ductoscopic examination combined with liquid-based cytologic test,and biopsy of surgical specimens were compared.Results Results of the biopsy of surgical specimens showed that 70 cases of papillary tumor,6 cases of ductal hyperplasia,4 cases of breast cancer and 20 cases of other benign breast lesions.Results of the firberoptic ductoscopic examination revealed 55 cases of papillary tumors,3 cases of ductal hyperplasia,2 cases of breast cancer and 40 cases of other benign breast lesions.Results of liquid-based cytologic test showed 53 cases of papillary tumor,2 cases of ductal hyperplasia,2 cases of breast cancer and 43 cases of other benign breast lesions.Results of the firberoptic ductoscopic examination combined with liquid-based cytologic test showed 65 cases of papillary tumor,5 cases of ductal hyperplasia,3 cases of breast cancer and 27 cases of other benign breast lesions.The coincidence rate of the firberoptic ductoscopic examination in diagnosing intraductal proliferative lesions(papillary neoplasm,ductal hyperplasia and breast cancer)was 75%(60/80).The coincidence rate of the liquid-based cytologic test in diagnosing intraductal proliferative lesions(papillary neoplasm,ductal hyperplasia and breast cancer)was 71.25%(57/80).The coincidence rate of the firberoptic ductoscopic examination combined with liquid-based cytologic test in diagnosing intraductal proliferative lesions(papillary neoplasm,ductal hyperplasia and breast cancer)was 91.25%(73/80).The diagnostic coincidence rate of the firberoptic ductoscop

关 键 词：纤维乳管镜检查 液基细胞学检查 乳头溢液 乳腺导管内增生性病变 

分 类 号：R737.9[医药卫生—肿瘤]