妊娠中期血清绒毛膜促性腺激素联合甲胎蛋白、雌三醇进行唐氏综合征筛查的临床价值  

Clinical value of serum chorionic gonadotropin combined with alpha fetoprotein and estriol in screening Down’s syndrome in women at the second trimester of pregnancy

作　　者：高兴华 GAO Xing-hua(Tieling Maternal and Infant Hospital,Tieling 112000,China)

机构地区：[1]铁岭市妇婴医院,112000

出　　处：《中国实用医药》2021年第36期79-81,共3页China Practical Medicine

摘　　要：目的探讨妊娠中期血清绒毛膜促性腺激素联合甲胎蛋白、雌三醇进行唐氏综合征筛查的临床价值。方法3178例孕妇,妊娠中期均接受血清绒毛膜促性腺激素联合甲胎蛋白、雌三醇检测。比较不同年龄段孕妇唐氏综合征高风险检出率;分析确诊为21-三体综合征及18-三体综合征孕妇的血清检查结果;血清绒毛膜促性腺激素联合甲胎蛋白、雌三醇检查结果。结果3178例孕妇中检出唐氏综合征高风险120例。673例15~24岁孕妇中,15例高风险,检出率为2.23%;1459例25~29岁孕妇中,36例高风险,检出率为2.47%;1046例30~41岁孕妇中,69例高风险,检出率为6.60%。孕妇年龄越大,唐氏综合征高风险检出率越高,不同年龄段孕妇唐氏综合征高风险检出率比较差异具有统计学意义(P<0.05)。120例高风险孕妇接受羊水穿刺和无创DNA检出21-三体综合征2例(1.67%)、18-三体综合征1例(0.83%),均放弃妊娠。余3175例孕妇中,分娩后进行随访,新生儿均健康。确诊的2例21-三体综合征风险值均明显≥1∶270,18-三体综合征风险值明显≥1∶350。3178例孕妇,接受血清绒毛膜促性腺激素联合甲胎蛋、雌三醇检查后,共检出120例阳性(3.75%),以羊水穿刺和无创DNA检查结果作为金标准,联合检测结果中真阳3例、假阳117例、真阴3058例、假阴0例。结论临床在筛查唐氏综合征时,检测妊娠中期孕妇的血清绒毛膜促性腺激素联合甲胎蛋白、雌三醇指标,有助于为临床医师判断疾病提供可靠的依据。Objective To evaluate the clinical value of serum chorionic gonadotropin combined with alpha fetoprotein and estriol in screening Down’s syndrome in women at the second trimester of pregnancy.Methods 3178 women at the second trimester of pregnancy were tested for serum chorionic gonadotropin combined with alpha fetoprotein and estriol.The high-risk detection rates of Down’s syndrome in pregnant women of different ages were compared.The serum examination results of pregnant women who were confirmed as trisomy 21 syndrome and trisomy 18 syndrome were analyzed.Results of serum chorionic gonadotropin combined with alpha fetoprotein and estriol were analyzed.Results 120 cases with high risk of Down syndrome were detected in 3178 pregnant women.Among 673 pregnant women with age of 15-24 years,15 cases were at high risk,and the detection rate was 2.23%.Among 1459 pregnant women with age of 25-29 years,36 cases were at high risk,and the detection rate was 2.47%.Among 1046 pregnant women with age of 30-41 years,69 cases were at high risk,and the detection rate was 6.60%.The older the pregnant women were,the higher the high-risk detection rate of Down’s syndrome was.The difference in the high-risk detection rate of Down’s syndrome among pregnant women of different ages was statistically significant(P<0.05).In 120 high-risk pregnant women who received amniocentesis and noninvasive DNA detection,2 cases(1.67%)of trisomy 21 syndrome and 1 case(0.83%)of trisomy 18 syndrome gave up pregnancy.The remaining 3175 pregnant women were followed up after delivery,and all of the newborns were healthy.The risk value of 2 cases conformed as trisomy 21 syndrome was significantly≥1∶270,and the risk value of 2 cases conformed as trisomy 18 syndrome was significantly≥1∶350.After 3178 pregnant women received tests for serum chorionic gonadotropin combined with alpha fetoprotein and estriol,120 cases(3.75%)were found positive.Results of amniocentesis and noninvasive DNA examination were used as the gold standard,so results of t

关 键 词：妊娠中期 血清绒毛膜促性腺激素 甲胎蛋白 雌三醇 唐氏综合征 

分 类 号：R714.5[医药卫生—妇产科学]