长链非编码RNA SOX2OT在肝细胞癌组织中的表达及与预后的相关性  

Expression of long non-coding RNA SOX2OT in hepatocellular carcinoma tissues and its correlation with prognosis

作　　者：廖豪杰 李俊[1] 熊海林[1] 袁霞[1] 袁乐中 LIAO Hao-jie;LI Jun;XIONG Hai-lin(Central People's Hospital of Huizhou,Huizhou Guangdong,516000,China)

机构地区：[1]广东省惠州市中心人民医院,广东惠州516000

出　　处：《中西医结合肝病杂志》2021年第12期1082-1084,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨长链非编码RNA(lncRNA)SOX2OT在肝细胞癌(HCC)组织中的表达情况,分析其与患者预后的相关性。方法:2017年1月至2019年6月收治的HCC患者120例,采用实时荧光定量PCR(qRT-PCR)检测lncRNA SOX2OT在HCC组织及癌旁组织中的表达,分析lncRNA SOX2OT的表达与HCC患者临床病理参数及预后的关系,采用COX回归模型分析影响HCC患者生存的危险因素。结果:lncRNA SOX2OT在HCC组织中的表达水平明显高于癌旁组织[(3.78±0.41)vs(1.53±0.22),(P<0.05)]。120例HCC患者中,lncRNA SOX2OT高表达72例,低表达48例;lncRNA SOX2OT的表达与肿瘤病灶数目、分化程度、远处转移及HBV水平均存在明显相关性(P<0.05)。lncRNA SOX2OT高表达HCC患者的3年无瘤生存率[25.00%(18/72)vs 64.58%(31/48)]及总生存率[41.67%(30/72)vs 85.42%(41/48)]均明显低于低表达HCC患者(P<0.05)。低分化程度[HR(95%CI)=1.043(0.997~2.691)、2.3274(1.617~5.635)]、有远处转移[HR(95%CI)=5.825(1.313~28.190)、6.484(1.902~23.442)]及lncRNA SOX2OT高表达[HR(95%CI)=3.225(1.492~8.667)、3.513(1.702~8.847)]是影响HCC患者无瘤生存率及总生存率的独立危险因素(P<0.05)。结论:lncRNA SOX2OT在HCC组织中的高表达与患者的预后不良有关。Objective:To investigate the expression of long non-coding RNA(lncRNA)SOX2OT in hepatocellular carcinoma(HCC)tissues and analyze its correlation with the prognosis of patients.Methods:A total of 120 HCC patients were treated from January 2017 to June 2019.The quantitative real-time PCR(qRT-PCR)was used to detect the expression of LncRNA SOX2OT in HCC tissues and adjacent tissues.The relationship between the expression of LncRNA SOX2OT and clinicopathological parameters and prognosis of HCC patients were analyzed.COX regression model was used to analyze the risk factors affecting the survival of HCC patients.Results:The expression level of lncRNA SOX2OT in HCC tissues was significantly higher than that in paracancer tissue[(3.78±0.41)vs(1.53±0.22),(P<0.05)].Among the 120 HCC patients,there were 72 cases with high expression and 48 cases with low expression of lncRNA SOX2OT.The expression of LncRNA SOX2OT was significantly correlated with tumor lesion number,differentiation degree,distant metastasis and HBV level(P<0.05).The 3-year disease-free survival rate[25.00%(18/72)vs 64.58%(31/48)]and overall survival rate[41.67%(30/72)vs 85.42%(41/48)]of HCC patients with high expression of lncRNA SOX2OT was significantly lower than HCC patients with low expression(P<0.05).The poorly differentiation degree[HR(95%CI)=1.043(0.997~2.691),2.3274(1.617~5.635)],distant metastasis HR(95%CI)=5.825(1.313~28.190),6.484(1.902~23.442)]and high expression of lncRNA SOX2OT[HR(95%CI)=3.225(1.492~8.667),3.513(1.702~8.847)]was independent risk factor affecting the disease-free survival and overall survival rate of HCC patients(P<0.05).Conclusion:The high expression of lncRNA SOX2OT in HCC tissues was associated with poor prognosis of patients.

关 键 词：肝细胞癌 长链非编码RNA SOX2O 预后 

分 类 号：R735.7[医药卫生—肿瘤]