眼内液检测在病毒性视网膜炎中的临床应用  

Clinical application of intraocular fluid detection in viral retinitis

作　　者：郝昕蕾 肖璇[1] 金玮[1] 王文俊[1] 袁满 陈刘贵 杨安怀[1] HAO Xinlei;XIAO Xuan;JIN Wei;WANG Wenjun;YUAN Man;CHEN Liugui;YANG Anhuai(Eye Center,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院眼科中心,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2022年第1期153-157,共5页Medical Journal of Wuhan University

基　　金：湖北省自然科学基金面上项目(编号:2019CFB489)。

摘　　要：目的:探讨眼内液检测在病毒性视网膜炎中的临床应用。方法:对2019年6月至2021年2月在武汉大学人民医院就诊并进行眼内液检测的病例进行分析。10例病毒性视网膜炎为本文主要研究对象,10例非感染性葡萄膜炎作为对照。患者入院时已完善眼科检查,诊断不明确者行眼内液检测。结果:10例病毒性视网膜炎中,7例为水痘-带状疱疹病毒感染,2例为巨细胞病毒感染,1例为单纯疱疹病毒感染。细胞因子中IL-6、IL-8含量与病毒拷贝量之间存在显著正相关关系(P=0.005,rs=0.806;P=0.005,rs=0.806),而其它细胞因子如IL-10、VEGF、VCAM、BFGF含量与病毒拷贝量之间无明显相关性。IL-6、IL-8、IL-10、VCAM含量在病毒性视网膜炎和非感染性葡萄膜炎之间具有显著性差异(P≤0.001)。IL-8、IL-10、VCAM检测的阳性率在两类患者中具有显著性差异(P=0.003,0.011,0.001)。结论:病毒性视网膜炎患者眼内炎症反应较重,炎症程度与病毒核酸拷贝量之间存在正相关关系。Objective:To investigate the clinical application of intraocular fluid examination for in patients with viral retinitis.Methods:Patients conducted with intraocular fluid examination from June 2019 to February 2021 were included in the study.Ten cases of viral retinitis were the study subjects of this study,and 10 cases of non-infectious uveitis were set as the controls.All patients had completed ophthalmic examination,and intraocular fluid examination was performed if the diagnosis was still not clear.Results:Among the 10 patients with viral retinitis,7 were infected by varicella-zoster virus,2 were infected by cytomegalovirus,and one case was infected by herpes simplex virus.There were significant positive correlations between the levels of cytokines IL-6 or IL-8 and the number of viral copies(P=0.005,rs=0.806;P=0.005,rs=0.806),and there was no significant correlation between the other cytokines such as IL-10,VEGF,VCAM,or BFGF and virus copies.The levels of IL-6,IL-8,IL-10,and VCAM were significantly different between patients with viral retinitis and patients with non-infectious uveitis(P≤0.001).The positive rates of IL-8,IL-10,and VCAM were significantly different between the two types of patients(P=0.003,0.011,and 0.001,respectively).Conclusion:Patients with viral retinitis had severe inflammatory reaction and there was a positive correlation between the degree of inflammation and viral nucleic acid copies.

关 键 词：眼内液 病毒性视网膜炎 核酸 细胞因子 

分 类 号：R774.11[医药卫生—眼科]