细胞衰老及通讯研究  

Cellular Communications during Senescence

作　　者：张悦 朱元正 SAEED Muhammad 吴安东 胡成钰[2] 田小利[1,2] ZHANG Yue;ZHU Yuanzheng;SAEED Muhammad;WU Andong;HU Chengyu;TIAN Xiaoli(Aging and Vascular Diseases,Human Aging Research Institute(HARI),Nanchang University and Jiangxi Key Laboratory of Human Aging,Nanchang 330031;School of Life Science,Nanchang University,Nanchang 33003)

机构地区：[1]南昌大学生命科学学院及人类衰老研究所江西省人类衰老重点实验室衰老与血管病研究室,南昌330031 [2]南昌大学生命科学学院,南昌330031

出　　处：《中国基础科学》2021年第5期48-58,共11页China Basic Science

基　　金：国家重点研发计划项目(2020YFC2002900);国家自然科学基金重点项目(81630034);江西省基础研究计划重点项目(20192ACB70002);江西省重点研发计划项目(20181ACB20017);江西省基地与人才计划项目(20181BCD40001)。

摘　　要：细胞衰老是以不可逆转的细胞周期停滞为特征,是一个程序化且同时受环境因素影响的生理过程。大分子损伤与修复失衡,如DNA损伤和端粒功能障碍、原癌基因过度激活及其他外源刺激,可导致细胞衰老的发生。衰老细胞的特征之一是产生衰老相关分泌表型(senescence-associated secretory phenotype,SASP),并由此影响细胞间通讯,达到促进炎症反应、组织分化、创面愈合、抑制肿瘤及衰老细胞的清除等目的。本文以血管内皮细胞衰老为例,探讨SASP通过影响细胞通讯参与细胞损伤、修复,阐述其在心血管疾病中的作用,展望通过影响SASP干预衰老进程和衰老相关疾病发生的可能性。Cell senescence is characterized by irreversible cell cycle arrest,which is a programmed biological process but affected by environmental factors.The imbalance between macromolecular damage and repair,such as DNA damage,telomere dysfunction,excessive activation of proto-oncogenes,and other exogenous stimuli,can all lead to cell senescence.One of the characteristics of senescent cells is the development of senescence-associated secretory phenotype(SASP),which affects cell-to-cell communications and promotes inflammatory responses,tissue differentiation,wound healing,tumor inhibition,and senescent cells clearance.Here,we take senescent vascular endothelial cells as a model,discuss importance of SASP in cellular communications as well as in cardiovascular diseases,and explore the possible uses of SASP to intervene aging and diseases.

关 键 词：细胞衰老 细胞通讯 衰老相关分泌表型 血管稳态维持 血管相关疾病 

分 类 号：Q255[生物学—细胞生物学]