儿童蛋白丢失性胃肠病的诊断和治疗进展  

Progress in the Diagnosis and Treatment of Protein-losing Gastroenteropathy in Children

作　　者：郝建云 钟雪梅[1] HAO Jianyun;ZHONG Xuemei(Department of Gastroenterology,Children′s Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院消化内科,北京100020

出　　处：《医学综述》2022年第1期112-116,共5页Medical Recapitulate

基　　金：北京市医院管理局消化内科学科协同发展中心消化专项重点项目子课题(XXZ0505)。

摘　　要：蛋白丢失性胃肠病(PLG)以水肿、低血清蛋白血症为主要表现,由多种胃肠道及非胃肠道疾病病因所致的肠道蛋白质过度丢失引发,它并不是一个独立的疾病,而是由多种病因引起的一组临床综合征,实验室检查表现为血清总蛋白、白蛋白及球蛋白同时下降。目前,PLG的诊断为排除性诊断,在排除引起低蛋白血症的其他疾病的基础上诊断,α_(1)-抗胰蛋白酶清除率及核素影像学可辅助诊断。针对基础病因的治疗及膳食调整是PLG的主要治疗手段,预后取决于原发疾病。Protein-losing gastroenteropathy(PLG)is characterized by edema and hypoalbuminemia,which is induced by excessive loss of intestinal protein caused by a variety of gastrointestinal and non-gastrointestinal diseases.It is not an independent disease,but a group of clinical syndromes caused by a variety of etiologies.Laboratory examination manifestations are simultaneous decrease of total serum protein,albumin and globulin.At present,the diagnosis of PLG is an exclusive diagnosis,which is diagnosed on the basis of excluding other diseases causing hypoproteinemia,andα_(1)-antitrypsin clearance rate and radionuclide imaging can assist in the diagnosis.The treatment targeting the basic etiology and dietary adjustment are the main treatment methods of PLG,and the prognosis depends on the primary disease.

关 键 词：蛋白丢失性胃肠病 低蛋白血症 儿童腹泻 

分 类 号：R574[医药卫生—消化系统]