补充益生菌对接种流行性感冒疫苗后抗体滴度影响的Meta分析  

The effect of probiotic supplementation on antibody titers after influenza vaccination:a Meta-analysis

作　　者：邓璐 陈莉婧[2] 汪铁山[2] DENG Lu;CHEN Lijing;WANG Tieshan(Changning Women and Child's Hospital,Changning 421500,China;Guangdong Women and Child's Hospital,Guangzhou 511400,China)

机构地区：[1]常宁市妇幼保健院,湖南常宁421500 [2]广东省妇幼保健院,广东广州511400

出　　处：《临床医药实践》2022年第1期3-9,共7页Proceeding of Clinical Medicine

摘　　要：目的:研究补充益生菌对接种流行性感冒(以下简称流感)疫苗后抗体滴度的影响。方法:计算机检索PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI,收集补充益生菌对接种流感疫苗后抗体滴度影响的研究,用Review manager 5.0软件进行Meta分析。采用均数和95%置信区间(95%CI)评价补充益生菌对接种流感疫苗后抗体滴度的影响。结果:纳入7项随机对照临床研究,共计476例患者,Meta分析结果表明:补充益生菌可提高接种流感疫苗后甲型H1N1型流感抗体滴度(MD=4.710,95%CI:0.53~8.89,P<0.00001;I^(2)=97%);补充益生菌可提高接种流感疫苗后甲型H3N2型流感抗体滴度(MD=16.86,95%CI:0.87~32.85,P<0.0001,I^(2)=100%);补充益生菌可提高接种流感疫苗后乙型流感抗体滴度(MD=3.04,95%CI:-0.77~6.85,P<0.0001,I^(2)=96%)。结论:补充益生菌可提高接种流感疫苗后甲型H1N1流感、甲型H3N2流感和乙型流感抗体滴度。Objective:To evaluate the effect of probiotic supplementation on antibody titers after influenza vaccination.Methods:The PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI databases were searched for RCTs.All eligible studies were randomized controlled trials assessing the effect of probiotic supplementation on antibody titers after influenza vaccination.The data were analyzed by Review Manager 5.0 software.Mean Difference(MD)with 95%confidence intervals(CIs)were used to measure the effect of probiotic supplementation on antibody titers after influenza vaccination.Results:Seven RCTs reporting data on 476 patients were finally included.Patients with probiotics supplements were found to have higher influenza hem agglutination inhibition antibody titers after vaccination(for A/H1N1,MD=4.710;95%CI:0.53~8.89;P<0.00001,I^(2)=97%;for A/H3N2,MD=16.86;95%CI:0.87~32.85;P<0.0001;I^(2)=100%;for B strain,MD=3.04;95%CI:-0.77~6.85;P<0.0001;I^(2)=96%).Conclusion:Supplementation with probiotics may enhance the influenza hemagglutination inhibition antibody titers in all A/H1N1,A/H3N2,and B strains.

关 键 词：益生菌 流感疫苗 抗体滴度 META分析 

分 类 号：R575[医药卫生—消化系统]