疼痛管理对肝癌患者术后疼痛因子水平及心理状态的影响  

Effect of pain management on postoperative pain factors and psychological status of patients with liver cancer

作　　者：张燕[1] 周晓萍 王可 李婷[4] 齐红杰 程田[5] ZHANG Yan#;ZHOU Xiaoping;WANG Ke;LI Ting;QI Hongjie;CHENG Tian(Outpatient Clinic,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Obstetrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Orthopedics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第一附属医院门诊,郑州450000 [2]郑州大学第一附属医院产科,郑州450000 [3]郑州大学第一附属医院眼科,郑州450000 [4]郑州大学第一附属医院外科,郑州450000 [5]郑州大学第一附属医院骨科,郑州450000

出　　处：《癌症进展》2021年第22期2363-2366,共4页Oncology Progress

摘　　要：目的研究疼痛管理对肝癌患者术后疼痛因子水平及心理状态的影响。方法将110例肝癌患者按管理方法不同分为观察组54例和对照组56例,对照组采用常规管理干预,观察组在对照组基础上采用疼痛管理干预。比较两组患者干预前后神经生长因子(NGF)、前列腺素E_(2)(PGE_(2))、神经肽Y(NPY)、丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)水平,抑郁自评量表(SDS)、焦虑自评量表(SAS)评分及不良反应发生情况。结果干预后,两组患者NGF、PGE_(2)、NPY、ALT、AST水平及SAS、SDS评分均降低(P﹤0.05),且观察组患者NGF、PGE_(2)、NPY、ALT、AST水平及SAS、SDS评分均明显低于对照组(P﹤0.01)。观察组患者呼吸困难发生率低于对照组,差异有统计学意义(P﹤0.05)。结论疼痛管理对降低肝癌患者术后疼痛因子水平、改善肝功能情况、调节心理状态效果较好,不良反应也较小。Objective To study the effect of pain management on postoperative pain factor levels and psychological status of patients with liver cancer.Method A total of 110 patients with liver cancer were divided into observation group(54 cases)and control group(56 cases)according to different intervention methods.The control group adopted routine management intervention,and the observation group adopted pain management intervention based on the control group’s regimen.The levels of indicators including nerve growth factor(NGF),prostaglandin E_(2)(PGE_(2)),neuropeptide Y(NPY),alanine aminotransferase(ALT),and aspartate aminotransferase(AST),and the scores from scales including self-rating depression scale(SDS)and self-rating anxiety scale(SAS)before and after the intervention and the occurrence of adverse events were compared between the two groups.Result After the intervention,the levels of NGF,PGE_(2),NPY,ALT,AST and the scores of SAS and SDS of the two groups decreased(P<0.05),and the levels of NGF,PGE_(2),NPY,ALT,AST and the scores of SAS and SDS of the observation group were all significantly lower than the control group(P<0.01).The incidence of dyspnea in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Pain management can obtain a better effect on reducing postoperative pain factor levels,improving liver function,and regulating psychological status in patients with liver cancer with a lower risk of adverse events.

关 键 词：肝癌 疼痛管理 疼痛因子 心理状态 

分 类 号：R735.7[医药卫生—肿瘤]