Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma  

作　　者：Xiaoli Cai Mingming Wang Peng Mu Tengyue Jian Dong Liu Shichao Ding Yanan Luo Dan Du Yang Song Chun-Long Chen Yuehe Lin 

机构地区：[1]School of Mechanical and Materials Engineering,Washington State University,PO Box 642920 Pullman,Washington 99164,USA [2]Physical Sciences Division,Pacific Northwest National Laboratory,Richland,WA 99352,USA [3]Department of Mechanical Engineering and Materials Science and Engineering Program,State University of New York,Binghamton,New York 13902,USA

出　　处：《Research》2021年第1期1379-1390,共12页研究（英文）

基　　金：supported by Washington State University(WSU)start-up fund.Peptoid synthesis work was supported by the Materials Synthesis and Simulation Across Scales(MS3)Initiative through the LDRD fund at Pacific Northwest National Laboratory(PNNL);Assembly of peptoid nanotubes and their structural characterizations were supported by the U.S.Department of Energy,Office of Basic Energy Sciences,Biomolecular Materials Program at PNNL;the Advanced Light Source with support from the Molecular Foundry,at Lawrence Berkeley National Laboratory,both of which are supported by the Office of Science,under Contract No.DE-AC02-05CH11231;PNNL is a multiprogram national laboratory operated for Department of Energy by Battelle under Contract No.DE-AC05-76RL01830.

摘　　要：Near-infrared(NIR)laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy.However,insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen(1 O2)distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes.To achieve high tumor killing efficacy,one of the solutions is to employ the combinational treatment of phototherapy with other modalities,especially with chemotherapeutic agents.In this paper,a simple and effective multimodal therapeutic system was designed via combining chemotherapy,photothermal therapy(PTT),and photodynamic therapy(PDT)to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the brain.IR-780(IR780)dye-labeled tube-forming peptoids(PepIR)were synthesized and self-assembled into crystalline nanotubes(PepIR nanotubes).These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density;thus,a self-quenching of these IR780 molecules was significantly reduced.Moreover,the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma cells.Given the unique properties of peptoids and peptoid nanotubes,we believe that the developed multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.

关 键 词：CHEMOTHERAPY IR780 MODAL 

分 类 号：R730.5[医药卫生—肿瘤]