Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study  

作　　者：Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi 

机构地区：[1]CHESS Center,Institute of Portal Hypertension,The First Hospital of Lanzhou University,Lanzhou,Gansu,China [2]CHESS Center,The Sixth People’s Hospital of Shenyang,Shenyang,Liaoning,China [3]Department of Infectious Disease,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,China [4]Department of Microbiology and Infec-tious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center,Beijing,China [5]Depart-ment of Radiology,Zhongda Hospital,Medical School of Southeast University,Nanjing,Jiangsu,China [6]Istanbul Health and Technology University,Zytinburnu/İstanbul,Turkey [7]CHESS Working Party,Xingtai People’s Hospital,Xingtai,Hebei,China [8]Department of Hepatobiliary Surgery,The Third People’s Hospital of Shenzhen,Shenzhen,Guangdong,China [9]Department of Radiology,Fifth Medical Center of PLA General Hospital,Beijing,China [10]Department of Gastroenterol-ogy,Shandong Provincial Hospital Affiliated to Shandong University,Jinan,Shandong,China [11]Department of Radiology,IRCCS Azienda Ospedaliero-Universitaria di Bologna,University of Bologna,Italy [12]Department of Radiology,Ankara University School of Medicine,Ankara,Turkey [13]Department of Gastroenterology,Ankara University School of Medicine,Ankara,Turkey [14]Department of Hepatobiliary Surgery,People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan,Ningxia,China

出　　处：《Journal of Clinical and Translational Hepatology》2021年第6期818-827,共10页临床与转化肝病杂志（英文版）

基　　金：the National Natural Science Foundation of China(81830053,82001780);Guangzhou Industry-Academia-Research Collaborative Innovation Major Project(201704020015);Natural Science Foundation of Jiangsu Province of China(BK20200361);President Foundation of Nanfang Hospital,Southern Medical University(2017Z012);Distinguished Young Scholars of Gansu Province(20JR10RA713).

摘　　要：Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis.

关 键 词：Liver cirrhosis Advanced chronic liver disease Hepatic venous pressure gradient Liver surface nodularity Imaging 

分 类 号：R57[医药卫生—消化系统]