Clinical Significance of Liver Function Abnormality in Patients with COVID-19:A Single-center Experience from Western India  

作　　者：Chetan R.Kalal Harshad Joshi Vivek Kumar Divya Gopal Darshana Rathod Ashish Shukla Tarang Gianchandani Chetan Bhatt 

机构地区：[1]Department of Gastroenterology,Hepatology and Liver Transplant,Sir HN Reliance Foundation Hospital and Research Cen-tre,Mumbai,Maharashtra,India [2]Department of Critical Care,Sir HN Reliance Foundation Hospital and Research Centre,Mumbai,Maharashtra,India [3]Department of Administration,Sir HN Reliance Foundation Hospital and Research Centre,Mumbai,Maharashtra,India

出　　处：《Journal of Clinical and Translational Hepatology》2021年第6期878-888,共11页临床与转化肝病杂志（英文版）

摘　　要：Background and Aims:The impact of coronavirus disease-2019(COVID-19)on liver function remains to be fully elucidated.This study was designed to investigate such and determine the clinical significance in determining mortality risk.Methods:A retrospective study was conducted in patients with COVID-19 from March 2020 to July 2020.Clinical details were retrieved from electronic medical records to obtain clinical characteristics,medical history,laboratory tests,therapeutic intervention,and outcome data.Results:A total of 184 patients with COVID-19 were included(median age:45.5 years),comprised of 62.5%men.In total,22(12.0%)patients had severe infection and 162(88.0%)had mild to moderate infection.Overall,95(51.6%)showed abnormal liver function test(LFT)and 17(9.2%)showed normal LFT at admission.The median age,hospital stay,and LFT were significantly higher in severe vs.non-severe infection(p<0.001).Out of 12 deaths,the majority were due to severe infection(n=11).Deaths were also due to acute respiratory distress syndrome(n=5),cardiac reasons(n=3),and sepsis with multiorgan failure(n=3).The median age,hospital stay and number of intensive care unit admissions were higher in patients having abnormal LFT compared to normal LFT.Incidence of elevated aspartate aminotransferase(42.8%and 40.4%),alanine transaminase(43.7%and 41.6%),and hypoalbuminemia(71.4%and72.7%)at admission and discharge were more common in severe infection.The mean survival was significantly lower in severe infection compared to those with non-severe disease(17.2 vs.52.3 days;p<0.001).Conclusions:Incidence of abnormal liver function was higher in patients with severe COVID-19 and was associated with prolonged hospital stay;mortality was associated with severity of COVID-19.For ruling out the risk of liver injury,it is crucial to vigilantly monitor the liver function parameters in patients with COVID-19 admitted to hospital.

关 键 词：ALT/AST Hospital stay HYPOALBUMINEMIA Liver injury Severe disease 

分 类 号：R73[医药卫生—肿瘤]