p53、p16及HER-2蛋白在子宫内膜癌组织中的表达及与临床病理特征的关系研究  

Expression of p53,p16 and HER-2 proteins in endometrial carcinoma and their relationship with clinicopathological features

作　　者：傅建辉 Fu Jian-hui(Fujian Maternal and Child Health Hospital,Fuzhou 350000,China)

机构地区：[1]福建省妇幼保健院,福建福州350000

出　　处：《四川生理科学杂志》2021年第10期1661-1663,1734,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:研究分析子宫内膜癌组织中p53、p16及HER-2蛋白表达与患者临床病理特征之间的关系。方法:选取我院2017年6月至2021年3月收治的70例经术后病理学检查确诊的子宫内膜癌患者作为研究对象。采用免疫组化法对患者病理组织中p53、p16及HER-2蛋白表达进行检测,并分析这三种蛋白的表达与癌症发生、病理类型、分化程度、FIGO分期的关系。结果:与癌旁组织相比,癌组织p53及HER-2阳性率更高(P<0.05),p16阳性率更低(P<0.05);p53、p16以及HER-2在腺癌与非腺癌组织中的阳性率无明显差异(P>0.05);p16阳性率在G_(2)级患者组织中最高,G_(3)级次之,G_(1)级患者组织中最低(P<0.05),p53、HER2阳性率在G_(1)级患者组织中最高,G_(2)级次之,G_(3)级患者组织中最低(P<0.05);与Ⅰ期、Ⅱ期患者相比,Ⅲ期、Ⅳ期患者p53、HER-2阳性率均更高(P<0.05),而p16阳性率更低(P<0.05);子宫内膜癌组织分级和分期与p53、HER-2阳性表达为正相关关系(P<0.05),与p16阳性表达为负相关关系(P<0.05)。结论:子宫内膜癌患者临床病理特征与p16表达降低及p53、HER-2表达升高存在明显相关性,可为临床治疗及患者预后评估提供依据和参考。Objective:To study and analyze the relationship between the expression of p53,p16 and HER-2 protein in endometrial cancer tissues and the clinicopathological characteristics of patients.Methods:A total of 70 patients with endometrial cancer diagnosed by postoperative pathological examinations admitted to our hospital from June 2017 to March 2021 were selected as the research objects.Immunohistochemical method was used to detect the expression of p53,p16 and HER-2 protein in the patient's pathological tissue,and the relationship between the expression of these three proteins and the occurrence of cancer,pathological type,degree of differentiation,and FIGO stage was analyzed.Results:Compared with adjacent tissues,the positive rates of p53 and HER-2 in cancer tissues were higher(P<0.05),and the positive rates of p16 were lower(P<0.05);p53,p16 and HER-2 were found in adenocarcinoma and nonglandular tissues.There was no significant difference in the positive rate in cancer tissues(P>0.05);the positive rate of p16 was the highest in the tissues of G_(2) patients,followed by G_(3),and the lowest in G_(1) patients(P<0.05).The positive rates of p53 and HER-2 were It was the highest in G_(1) patient tissue,followed by G_(2),and the lowest in G_(3) patient tissue(P<0.05);compared with patients in stage I and II,the positive rates of p53 and HER-2 were higher in patients in stage III and IV.High(P<0.05),while the positive rate of p16 is lower(P<0.05);the grade and staging of endometrial cancer are positively correlated with the positive expression of p53 and HER-2(P<0.05),and the positive expression of p16 is Negative correlation(P<0.05).Conclusion:The clinicopathological characteristics of patients with endometrial cancer are significantly correlated with the decrease of p16 expression and the increase of p53 and HER-2 expression,which can provide basis and reference for clinical treatment and patient prognosis evaluation.

关 键 词：子宫内膜癌 临床病理特征 P53 P16 HER-2 

分 类 号：R73[医药卫生—肿瘤]