Association between GABRG2 rs211037 polymorphism and idiopathic generalized epilepsies:a meta-analysis  

作　　者：Xiaohui Yang Hongyun Ding Hongyun Wei Jia Liu Pingping Liao Yuzhu Zhang Xiaomeng Wang Xiaosa Chi 

机构地区：[1]Department of Respiratory,Affiliated Hospital of Qingdao University,Qingdao 266000,China [2]Department of Gastroenterology,Qingdao Municipal Hospital Group,Qingdao 266000,China [3]Department of Gastroenterology,Affiliated Hospital of Qingdao University,Qingdao 266000,China [4]Department of Geriatrics,Affiliated Hospital of Qingdao University,59 Haier Road,Qingdao,Shandong 266100,China

出　　处：《Acta Epileptologica》2021年第1期64-70,共7页癫痫学报（英文）

基　　金：supported by the National Natural Science Foundation of Shandong,China(item number ZR2019PH040);the National Natural Science Foundation of China(item number 81901321).

摘　　要：Background:We performed this meta-analysis to investigate the association between GABRG2 rs211037polymorphism and the risk for idiopathic generalized epilepsies(IGEs).Methods:Medline,Embase,Cochrane Library and Chinese National Knowledge Infrastructure(CNKI)databases were searched for eligible studies(until May 5,2020)on the association between GABRG2 rs211037 polymorphism and IGE.The odds ratios were calculated using a fixed or random model in STATA 15.0 software.Subgroup analyses for ethnicity,age,source of controls,type of seizure syndrome and therapeutic responses were conducted.Results:We found no significant associations between GABRG2 rs211037 polymorphism and the susceptibility to IGEs.In addition,no significant association was detected between GABRG2 rs211037 polymorphism and drug resistance in IGE patients.The results did not change after stratification by Asian population,healthy controls,children,juvenile myoclonic epilepsy,and childhood absence epilepsy.Conclusion:The current studies indicated that the GABRG2 rs211037 polymorphism was not related to susceptibility or drug resistance of IGE.Further well-designed studies are needed to verify the results.

关 键 词：GABRG2 rs211037 Idiopathic generalized epilepsies POLYMORPHISM 

分 类 号：R36[医药卫生—病理学]