Seizures in posterior reversible encephalopathy syndrome:blood pressure management in normotensive patients  

作　　者：Lu Lu Weixi Xiong Yingying Zhang Yingfeng Xiao Dong Zhou 

机构地区：[1]Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China

出　　处：《Acta Epileptologica》2021年第1期214-219,共6页癫痫学报（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(81801294,81871017,81420108014);the Post-Doctoral Research Project of West China Hospital at Sichuan University(2018HXBH023);the 1.3.5 Project for Disciplines of Excellence of West China Hospital at Sichuan University(ZY2017305,ZYGD20011).

摘　　要：Posterior reversible encephalopathy syndrome(PRES)is a rare clinical disease that refers to the subcortical vasogenic edema involving bilateral parieto-occipital regions,with a usually reversible syndrome when causes are eliminated or controlled.Hypertension or blood pressure fluctuations are most common causes of PRES,but other contributors like chemotherapy and autoimmune disorders have also been reported.PRES has rapid onset of symptoms.Therefore,it is of major importance to determine whether blood pressure management plays an important role in prognosis.We presented two PRES patients who developed non-convulsive seizure but had normal baseline blood pressure at the time of presence of cause.The diagnosis of PRES was made by neurologists.The patients had no history of seizure or hypertension,but during the disease course they presented with temporal elevation of blood pressure with different durations.The second patients without instant blood pressure control developed residual symptoms of seizure at 90-and 120-day follow-up.Although the exact pathophysiology of PRES remains to be fully understood,primary and secondary prolonged blood pressure fluctuations may be associated with the prognosis of this syndrome.Early blood pressure management would be critical to favorable outcome.

关 键 词：PATIENTS DIAGNOSIS CHEMOTHERAPY 

分 类 号：R73[医药卫生—肿瘤]