酸枣仁汤调节睡眠改善阿尔茨海默病患者认知功能的临床研究  

Clinical Study on the Effect of Suanzaoren Decoction on Improving Sleep and Cognitive Function in Patients with Alzheimer's Disease

作　　者：吴东南 陈影 赵燕青 肖政 邓旭辉 张子盈 WU Dong-nan;CHEN Ying;ZHAO Yan-qing;XIAO Zheng;DENG Xu-hui;ZHANG Zi-ying(Yuebei People's Hospital Affiliated to Shantou University,Shaoguan Guangdong 512400)

机构地区：[1]汕头大学附属粤北人民医院,广东韶关512400

出　　处：《世界中西医结合杂志》2021年第11期2129-2133,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：广东省中医药局科研项目(20201347);韶关市科技计划项目(200812084530302);韶关市卫生健康科研项目(Y19016)。

摘　　要：目的研究酸枣仁汤对阿尔茨海默病(Alzheimers disease,AD)患者睡眠质量、认知功能的临床疗效。方法选取2018年1月—2019年2月期间于粤北人民医院神经内科、老年病科、中医科门诊、住院部就诊的AD合并睡眠障碍患者58例,按随机数字表法分为对照组和治疗组,每组各29例。对照组给予盐酸多奈哌齐治疗,治疗组加用酸枣仁汤,两组均连续干预治疗6个月。观察比较两组患者治疗前后匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)、简易精神状态量表(Mini-Mental State Examination,MMSE)、AD评定量表-认知(ADAS-Cog)、日常生活能力量表(ADL)评分,评价中医证候临床疗效及不良反应情况。结果治疗后治疗组睡眠质量、睡眠时间、睡眠效率、日间功能、睡眠障碍、入睡时间评分及PQSI总分均较治疗前明显降低,且治疗组睡眠质量、睡眠时间、睡眠效率、日间功能、睡眠障碍、入睡时间评分及PQSI总分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后治疗组记忆能力、回忆能力评分均较治疗前明显升高,差异有统计学意义(P<0.05);且治疗组记忆能力、回忆能力评分均较对照组明显升高,差异有统计学意义(P<0.05)。治疗后治疗组词语回忆、回忆测试指令评分均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组词语回忆、回忆测试指令评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者ADL总分、PSMS评分均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组治疗后ADL总分、PSMS评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后治疗组总有效率为39.29(11/28)%,对照组为11.11%(3/27),两组比较,差异有统计学意义(P<0.05)。治疗期间,两组患者血、尿、便常规及肝肾功能,均未发现异常情况。结论酸枣仁汤有效改善AD患者睡眠质量的同时能一定程度减轻AD患者�Objective To study the clinical effect of Suanzaoren Decoction on sleep quality and cognitive function in patients with Alzheimer's disease.Methods Fifty-eight patients with Alzheimer's disease and sleep disorders who were treated in the Department of Neurology,Geriatrics,Traditional Chinese Medicine Clinic,and Inpatient Department of Yuebei People's Hospital from January 2018 to February 2019 were selected and divided into a treatment group(29 cases)and a control group(29 cases)according to the random number table method.The control group was treated with donepezil hydrochloride.The treatment group was treated with Suanzaoren Decoction on the basis of the control group.The two groups were intervened for six months.Before and after treatment,patients were scored on the Pittsburgh Sleep Quality Index Scale(PSQI),Mini Mental State Scale(MMSE),Alzheimer's Disease Rating Scale-Awareness(ADAS-Cog),and Ability to Daily Life Scale(ADL),and the Alzheimer's Disease Syndrome Element Scale(AD-PES-11)score;The clinical efficacy and adverse reaction of TCM syndromes were evaluated.Results After treatment,the sleep quality,sleep time,sleep efficiency,daytime function,sleep disturbance,falling asleep score and PQSI total score in the treatment group were significantly lower than before treatment,and the sleep quality,sleep time,sleep efficiency.And daytime of the treatment group function,sleep disturbance,sleep time score and total PQSI score were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the memory ability and recall ability scores of the treatment group were significantly higher than those before treatment,and the difference was statistically significant(P<0.05).And the memory ability and recall ability scores of the treatment group were significantly higher than those of the control group,and the difference was statistically significant significance(P<0.05).After treatment,the scores of word recall and recall test instructions in the treatment

关 键 词：阿尔茨海默病 酸枣仁汤 认知功能 睡眠 

分 类 号：R749.1[医药卫生—神经病学与精神病学]