补肾固齿丸辅助治疗广泛型重度牙周炎的随机对照临床研究  

Adjunctive effect of Bushenguchiwan in treatment of generalized severe periodontitis:a randomized clinical trial

作　　者：袁堂霞[1] 张彦表[1] Yuan Tangxia;Zhang Yanbiao(Department of Prosthodontics,School of Stomatology,Weifang Medical College,Weifang 261053,China)

机构地区：[1]潍坊医学院口腔医学院口腔修复教研室,山东潍坊261053

出　　处：《山东第一医科大学（山东省医学科学院）学报》2021年第12期903-907,共5页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：山东省中医药科技发展计划(2019-0436)。

摘　　要：目的探讨补肾固齿丸辅助龈下刮治和根面平整术(scaling and root planning,SRP)治疗广泛型重度牙周炎的临床疗效及其对血清超敏C反应蛋白(hsCRP)水平的影响。方法采用前瞻性单盲随机对照临床试验设计,将60例广泛型重度牙周炎患者,按计算机产生的随机数字表分为对照组(单纯SRP治疗组)和试验组(补肾固齿丸辅助SRP治疗组),每组30例,分析治疗前及治疗后3、6个月时菌斑指数(PLI)、探诊出血(BOP)、探诊深度(PD)、临床附着丧失(CAL)和hsCRP的变化。结果治疗后3、6个月时,两组各项观察指标与治疗前相比均显著降低,差异有统计学意义(P<0.05);试验组中袋(PD=4~6 mm)、深袋(PD≥7 mm)位点的PD、CAL降低值均大于对照组,差异有统计学意义(P<0.05);试验组BOP阳性位点百分比(BOP%)、PD≥5 mm位点百分比(PD≥5 mm%)、PD≥5 mm 且BOP阳性位点百分比(PD>5 mm且BOP%)及血清hsCRP水平均显著低于对照组,差异有统计学意义(P<0.05)。结论龈下刮治和根面平整术治疗广泛型重度牙周炎时辅助口服补肾固齿丸可取得更好的临床疗效,并可显著降低血清hsCRP水平。Objective:To evaluate the clinical effect of the use of Bushenguchiwan as adjuncts to scaling and root planing(SRP)in the treatment of generalized severe periodontitis and its effect on serum high sensitive C-reactive protein(hsCRP).Methods:In this 6-month prospective single-blind controlled randomized clinical trial,sixty subjects with generalized severe periodontitis were randomly assigned by 1:1 ratio to receive SRP alone or with Bushenguchiwan(0.4 g,b.i.d.)for 3 months.Plaque index(PLI),bleeding on probing(BOP),probing depth(PD),clinical attachment loss(GAL),and serum high sensitivity C-reactive protein(hsCRP)were monitored at baseline,3 and 6 months post-therapies.Results:Both treatments yielded statistically significant improvements in all monitored parameters at 3 and 6 months posttreatments,compared with baseline(P<0.05).The group receiving Bushenguchiwan exhibited greater reduction in the mean PD and CAL at initially intermediate(PD=4~6 mm)and deep(PD≥7 mm)sites than the SRP-only group at 3 and 6 months post-therapies(P<0.05).The SRP plus Bushenguchiwan group presented lower serum hsCRP as well as lower full-mouth mean percentage of sites with BOP,PD≥5 mm,and PD≥5 mm with BOP in comparison with the SRP-only group,at all follow-up evaluations(P<0.05).Conclusion:The adjunctive use of Bushenguchiwan significantly improves the clinical outcomes of SRP in the treatment of generalized severe periodontitis,and significantly reduces the serum hsCRP level.

关 键 词：补肾固齿丸 重度牙周炎 龈下刮治和根面平整术 超敏C反应蛋白 

分 类 号：R781.42[医药卫生—口腔医学]