增龄性神经系统改变对认知功能减退的作用机制研究进展  

Progress of the mechanism of aging patterns neurological changes on cognitive decline

作　　者：幸奠霞 吕洋[2] Xing Dianxia;Lü Yang(Department of Geriatrics,Chongqing University Three Gorges Hospital;Department of Geriatrics,The First Affiliated Hospital of Chongqing Medical University)

机构地区：[1]重庆大学附属三峡医院老年科,重庆404000 [2]重庆医科大学附属第一医院老年科,重庆400016

出　　处：《重庆医科大学学报》2021年第11期1399-1404,共6页Journal of Chongqing Medical University

基　　金：重庆市基础研究与前沿探索资助项目(编号:cstc2018jcyjAX0169)。

摘　　要：增龄导致的认知功能减退可造成巨大的家庭社会负担,其发病机制在近年来得到广泛研究。本文就增龄过程中神经系统代谢改变、神经元、胶质细胞、神经干细胞衰老及血脑屏障相关成分改变对认知功能的影响机制展开综述。The cognitive decline caused by aging can cause a heavy social burden,and its pathogenesis has been studied widely in recent years.In this paper,we review the metabolism of the nervous system,aging of neurons,glial cells,neural stem cells,changes of components related to the blood-brain barrier,and their effects on cognitive function during aging.

关 键 词：增龄 认知功能减退 神经系统改变 机制 进展 

分 类 号：R749.16[医药卫生—神经病学与精神病学]