淀粉-海藻酸盐复合止血材料的制备及性能研究  

Preparation and properties of alginate composite hemostatic materials

作　　者：朱肖杰 孟建文 朱小敏 罗西友 张素文 马学彬 杨忠波 ZHU Xiaojie;MENG Jianwen;ZHU Xiaomin;LUO Xiyou;ZHANG Suwen;MA Xuebin;YANG Zhongbo(Shandong Academy of Pharmaceutical Sciences,Shandong Provincial Key Laboratory of Biomedical Polymers,Jinan 250101,China;Shandong Yellow River Hospital,Yellow River Shandong Bureau,Jinan 250032)

机构地区：[1]山东省药学科学院,山东省医用高分子材料重点实验室,济南250101 [2]山东黄河河务局山东黄河医院,济南250032

出　　处：《生物医学工程研究》2021年第4期395-400,共6页Journal Of Biomedical Engineering Research

基　　金：山东省重点研发计划项目(2018GSF118052)。

摘　　要：本研究采用反相乳液法,制得淀粉-海藻酸盐复合止血材料。通过扫描电镜、吸液性能测试、体外凝血试验和大鼠肝脏止血试验对其物理形貌、吸液性能,体外凝血性能、动物止血效果进行研究。结果表明,淀粉-海藻酸盐复合止血材料表面呈粗糙、多孔状,对模拟体液的吸液倍率可达20~22倍。体外凝血试验中,淀粉-海藻酸盐复合止血材料的全血凝固时间比空白缩短了28.65%。大鼠肝脏止血试验,相对模型组止血时间缩短57.9%,出血量减少64.3%,在外科手术创面止血有着良好的应用前景。Starch-alginate composite hemostatic material was prepared by inverse emulsion method.The morphology,extracorporeal coagulation and hemostatic effect in animal experiments were studied by scanning electron microscopy,fluid absorption performance,in vitro coagulation test and rat liver hemostatic test.The results showed that the surface of starch-alginate composite hemostatic material was rough and porous,and the absorption rate of simulated body fluid reached 20~22 times.In vitro coagulation test,the coagulation time of blood was shorter 28.65%than that of blank test.Compared to model group,the hemostatic time of rat liver was reduced by 57.9%and the amount of blood loss was reduced by 64.3%.Therefore,the starch-alginate composite hemostatic material has a good application prospect in surgical wound hemostasis.

关 键 词：马铃薯淀粉 海藻酸钠 反相乳液 吸液能力 体外止血 动物实验 创面凝血 

分 类 号：R318[医药卫生—生物医学工程] O636[医药卫生—基础医学]