辽宁省城市膀胱癌患者10年生存率及其影响因素分析  

Analysis of the 10-year survival rate and its influencing factors of urban patients with bladder cancer in Liaoning Province

作　　者：郭薇[1] 李爽[1] 李恂[2] 张微微 李海娜[4] 潘国伟 穆慧娟[1] GUO Wei;LI Shuang;LI Xun;ZHANG Weiwei;LI Haina;PAN Guowei;MU Huijuan(Institute of Chronic Diseases,Liaoning Provincial Center for Disease Control and Prevention,Shenyang 110005,China;Institute of Chronic Dis­eases,Shenyang Center for Disease Control and Prevention,Shenyang 110031,China;Institute of Chronic Diseases,Anshan Center for Disease Control and Prevention,Anshan 114000,China;Institute of Chronic Diseases,Benxi Center for Disease Control and Prevention,Benxi 117000,China;Re­search Center for Universal Health,School of Public Health,China Medical University,Shenyang 110122,China)

机构地区：[1]辽宁省疾病预防控制中心慢性非传染性疾病预防控制所,沈阳110005 [2]沈阳市疾病预防控制中心慢病科,沈阳110031 [3]鞍山市疾病预防控制中心慢病科,辽宁鞍山114000 [4]本溪市疾病预防控制中心慢病科,辽宁本溪117000 [5]中国医科大学公共卫生学院全民健康研究中心,沈阳110122

出　　处：《中国医科大学学报》2022年第1期38-42,共5页Journal of China Medical University

基　　金：辽宁省自然科学基金(20180550495);辽宁省“兴辽英才计划”项目(XLYC1802131)。

摘　　要：目的探讨辽宁省城市膀胱癌患者10年生存率及其影响因素。方法采用主动结合被动随访的方式从辽宁省2000年肿瘤登记系统中抽取沈阳、鞍山和本溪3个市398例膀胱癌患者进行回顾性调查,计算观察生存率(OSR)、中位生存期(T50)、期望生存率(ESR)和相对生存率(RSR),并采用Cox回归模型分析患者的生存影响因素。结果辽宁省女性患者的10年RSR低于男性患者,≥65岁患者的10年OSR、RSR和T50低于<65岁患者,Ⅲ、Ⅳ期患者的10年OSR、RSR和T50低于Ⅰ、Ⅱ期患者,Ⅳ期患者的10年OSR和T50低于Ⅲ期患者,非手术治疗患者的10年OSR、RSR和T50低于手术治疗患者(均P<0.05)。多因素Cox回归分析结果显示,年龄每增加1岁,患者的相对死亡风险增加0.053倍;Ⅲ期和Ⅳ期患者的相对死亡风险分别为Ⅰ期患者的3.638和4.075倍;非手术治疗患者的相对死亡风险为手术治疗患者的2.384倍。结论辽宁省城市膀胱癌患者10年生存率低于同期发达国家,提高早诊早治率可有效提高其长期生存率。Objective To analyze the 10-year survival rate and its influencing factors of urban patients with bladder cancer in Liaoning Province.Methods A retrospective survey of 398 cases of bladder cancer in Shenyang,Anshan,and Benxi was conducted through active and passive follow-up.The overall survival rate(OSR),median survival time(T50),expected survival rate,and relative survival rate(RSR)were calculated,and a Cox regression model was used to analyze factors influencing patient survival.Results The 10-year RSR of women in Liaoning Province was lower than that of men,and the 10-year OSR,RSR,and T50 of patients aged≥65 years were lower than those of patients aged<65 years(P<0.05 in all cases).The 10-year OSR,RSR,and T50 of patients with stagesⅢandⅣwere lower than those of patients with stagesⅠandⅡ;the 10-year OSR and T50 of patients with stageⅣwere lower than those of patients with stageⅢ;and the 10-year OSR,RSR,and T50 in cases of non-operative treatment were lower than those in cases of operative treatment(P<0.05 in all cases).Multivariate Cox regression analysis revealed that the relative risk of death increased 0.053 times with a 1-year increase in age,3.638 times with stageⅢand 4.075 times with stageⅣ,and 2.384 times in cases of non-operative treatment.Conclusion The 10-year survival rate of patients with bladder cancer in Liaoning Province is lower than that of patients in developed countries.Ensuring early diagnosis and treatment can effectively improve the long-term survival rate.

关 键 词：膀胱癌患者 10年生存率 影响因素 城市 

分 类 号：R737.14[医药卫生—肿瘤]