Recent Developments in SARS-CoV-2 Neutralizing Antibody Detection Methods  

作　　者：Jo-Lewis BANGA NDZOUBOUKOU Yan-di ZHANG Xiong-lin FAN 

机构地区：[1]Department of Pathogen Biology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Current Medical Science》2021年第6期1052-1064,共13页当代医学科学（英文）

基　　金：supported by grants from the Applied Basic Research Key Project of Wuhan Municipal Bureau of Science and Technology(2020020601012218);the Fundamental Research Funds for the Central Universities(HUST COVID-19 Rapid Response Call No.2020kfyXGYJ040).

摘　　要：The ongoing Coronavirus disease 19 pandemic has likely changed the world in ways not seen in the past.Neutralizing antibody(NAb)assays play an important role in the management of the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)outbreak.Using these tools,we can assess the presence and duration of antibody-mediated protection in naturally infected individuals,screen convalescent plasma preparations for donation,test the efficacy of immunotherapy,and analyze NAb titers and persistence after vaccination to predict vaccine-induced protective effects.This review briefly summarizes the various methods used for the detection of SARS-CoV-2 NAbs and compares their advantages and disadvantages to facilitate their development and clinical application.

关 键 词：Coronavirus disease 19 severe acute respiratory syndrome coronavirus-2 neutralizing antibodies viral neutralization test plaque reduction neutralization test pseudovirus-based neutralization assays enzyme-linked immunosorbent assay lateral flow immunoassays 

分 类 号：R73[医药卫生—肿瘤]