HPV L1壳蛋白联合HR-HPV分型、TCT检测对宫颈癌前病变及宫颈癌的诊断价值分析  

Diagnostic value of HPV L1 capsid protein combined with HR-HPV typing and TCT for cervical precancerous lesions and cervical cancer

作　　者：李娜[1] 张改花 李娇[1] 朱广侠[1] 赵静妮[1] 付晶[1] LI Na;ZHANG Gaihua;LI Jiao;ZHU Guangxia;ZHAO Jingni;FU Jing(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院妇产科,710061 [2]西安交通大学第一附属医院心血管内科,710061

出　　处：《中国妇产科临床杂志》2022年第1期12-14,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：陕西省重点研发计划项目(2020SF-041)。

摘　　要：目的探究人乳头瘤病毒L1(HPV L1)壳蛋白联合高危型HPV(HR-HPV)分型、液基薄层细胞学(TCT)检测对宫颈癌前病变及宫颈癌的诊断价值。方法选取2018年5月至2020年2月在西安交通大学第一附属医院接受宫颈癌筛查的妇女1094例为对象,以组织病理学检查结果进行分组,比较各组HPV L1壳蛋白表达水平、HR-HPV和TCT检测阳性率。结果TCT检测阳性率与HR-HPV阳性率存在明显差异(P<0.05)。组织病理学检查,共检出正常或炎症179例(对照组)、CIN 1组26例、CIN 2组44例、CIN 3组40例和宫颈癌组21例,宫颈癌组的TCT检测阳性率和HR-HPV阳性率最高,HPV L1壳蛋白表达水平最低(P<0.05)。HPV L1壳蛋白联合HPV分型、TCT检测诊断宫颈癌前病变及宫颈癌的AUC值分别为0.897和0.804(P<0.05)。结论HPV L1壳蛋白、HPV分型和TCT检测在宫颈癌前病变及宫颈癌的诊断中具有一定的临床价值。Objective To explore the diagnostic value of human papilloma virus L1(HPV L1)capsid protein combined with high-risk HPV(HR-HPV)typing and thinprep cytology test(TCT)for cervical precancerous lesions and cervical cancer.Methods 1094 women who received cervical cancer screening were selected as the research subjects,and were grouped based on histopathological results.The expression level of HPV L1 capsid protein,and positive rates of HR-HPV and TCT were compared between the groups.Results There was a significant difference between TCT positive rate and HR-HPV positive rate(P<0.05).Histopathological examination found 179 normal cases or cases only with inflammation(control group),26 cases of CIN gradeⅠ(CIN1 group),44 cases of CIN gradeⅡ(CIN2 group),40 cases of CIN gradeⅢ(CIN3 group)and 21 cases of cervical cancer(cervical cancer group).The positive rates of TCT and HRHPV in cervical cancer group were the highest,and the expression level of HPV L1 capsid protein was the lowest(P<0.05).The AUC values of HPV L1 capsid protein combined with HPV typing and TCT to diagnose cervical precancerous lesions and cervical cancer were 0.897 and 0.804,respectively(P<0.05).Conclusion HPV L1 capsid protein,HPV typing and TCT are of clinical value in the diagnosis of cervical precancerous lesions and cervical cancer.

关 键 词：宫颈癌 宫颈癌前病变 人乳头瘤病毒L1壳蛋白 HPV分型 液基薄层细胞学 

分 类 号：R737.33[医药卫生—肿瘤]