注射用紫杉醇脂质体治疗晚期卵巢癌及对患者血清肿瘤标志物和免疫功能的影响  

Influence of paclitaxel liposome for injection on serum tumor markersand immune functionin patients with advanced ovarian cancer

作　　者：周敏 袁渊 朱明 卢佳 ZHOU Min;YUAN Yuan;ZHU Ming;LU Jia(Department of Gynecological Oncology,Shaanxi Provincial Cancer Hospital,Xi'an 710061,China)

机构地区：[1]陕西省肿瘤医院妇瘤科,西安710061

出　　处：《中国妇产科临床杂志》2022年第1期42-45,共4页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：陕西省科技厅一般项目(面上)(S2020-JC-YB-0675)。

摘　　要：目的研究注射用紫杉醇脂质体联合卡铂治疗晚期卵巢癌疗效及对患者血清癌抗原CA 125、CA153和CA199水平和免疫功能的影响,观察化疗不良反应的发生情况。方法选取2019年5月至2021年3月陕西省肿瘤医院的98例卵巢癌患者为样本进行随机对照研究,按照就诊顺序进行编号并采用随机数字表法均分为观察组和对照组各49例,观察组采用紫杉醇脂质体联合卡铂进行化疗,对照组采用紫杉醇注射液联合卡铂化疗,评估两组3个疗程后的临床疗效、肿瘤标志物、T淋巴细胞亚群分布及不良反应的发生情况。结果观察组和对照组治疗的有效率分别为72.34%和52.17%(P<0.05);3个疗程后两组血清CA125、CA153和CA199水平明显降低(P<0.05),且观察组血清CA125、CA153和CA199水平低于对照组,差异有统计学意义(P<0.05);3个疗程后两组外周血CD4+和CD4+/CD8+均明显降低(P<0.05),CD8+均明显升高(P<0.05),且观察组CD4+和CD4+/CD8+低于对照组,CD8+高于对照组,差异有统计学意义(P<0.05);观察组恶心呕吐、腹泻、白细胞减少、血小板减少、肝功能损害和肾功能损害发生率均明显低于对照组(P<0.05)。结论注射用紫杉醇脂质体联合卡铂治疗晚期卵巢癌可有效提升近期疗效,降低血清CA125、CA153和CA199水平,同时有利于减轻免疫功能损害并降低不良反应的发生率。Objective To study the efficacy of paclitaxel liposome for injection combined with carboplatin in the treatment of advanced ovarian cancer and its influence on levels of serum cancer antigen(CA)125,CA153 and CA199 and immune function,and observe the occurrence of adverse chemotherapy reactions.Methods 98 patients with ovarian cancer treated in Shanxi Provincial Cancer Hospital between May 2019 and March 2021 were selected as samples for the randomized controlled study.They were numbered according to the order of visit and equally divided into observation group and control group,with 49 cases in each group.The observation group was treated with paclitaxel liposome combined with carboplatin for chemotherapy,and the control group was treated with paclitaxel injection combined with carboplatin chemotherapy.The clinical efficacy,tumor markers,distribution of T lymphocyte subsets and occurrence of adverse reactions were evaluated after 3 courses of treatment in the two groups.Results The effective rates of treatment in the observation group and control group were 72.34%and 52.17%respectively(P<0.05).After 3 courses of treatment,the levels of serum CA125,CA153 and CA199 in the two groups were both significantly reduced(P<0.05),and those in observation group were lower than control group(P<0.05).After 3 courses of treatment,the peripheral blood CD4+and CD4+/CD8+of the two groups were significantly reduced(P<0.05)and the observation group were lower than control group.While the CD8+of the two groups were both significantly increased(P<0.05),and the observation group was higher(P<0.05).The incidence rates of nausea and vomiting,diarrhea,leukopenia,thrombocytopenia,liver function damage and kidney function damage were significantly lower in observation group than those in control group(P<0.05).Conclusion Paclitaxel liposome for injection combined with carboplatin in the treatment of advanced ovarian cancer can effectively improve the short-term efficacy,reduce the levels of serum CA125,CA153 and CA199,and help relieve the i

关 键 词：卵巢癌 晚期 化疗 脂质体紫杉醇 卡铂 肿瘤标志物 免疫功能 

分 类 号：R737.31[医药卫生—肿瘤]