大血管闭塞急性缺血性脑卒中超时间窗机械取栓研究现状  

Mechanical thrombectomy for acute ischemic stroke with large vessel occlusion beyond time window:current status

作　　者：张小曦 花伟龙 沈红健[1] 张磊[1] 张永鑫[1] 邢鹏飞[1] 李子付[1] 张永巍[1] 杨鹏飞[1] 刘建民[1] ZHANG Xiao-xi;HUA Wei-long;SHEN Hong-jian;ZHANG Lei;ZHANG Yong-xin;XING Peng-fei;LI Zi-fu;ZHANG Yong-wei;YANG Peng-fei;LIU Jian-min(Neurovascular Center,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)长海医院脑血管病中心,上海200433

出　　处：《第二军医大学学报》2022年第1期9-14,共6页Academic Journal of Second Military Medical University

基　　金：中国脑卒中高危人群干预适宜技术研究及推广项目(GN-2020R0008);上海市扬帆计划(20YF1448000);上海市临床重点专科项目(shslczdzk06101);海军军医大学(第二军医大学)长海医院青年启动基金(2018QNA007)。

摘　　要：血管再通治疗是大血管闭塞急性缺血性脑卒中(AIS-LVO)最主要的治疗方式。研究证实AIS-LVO机械取栓的明确时间窗为发病6 h内,对于发病6~24 h或超过24 h接受机械取栓的患者筛选仍存争议。本文对发病或末次正常时间为6~24 h的超时间窗AIS-LVO患者和超出24 h的超晚期AIS-LVO患者的机械取栓治疗现状进行总结,并分析延长取栓时间窗的可行性和评估策略。Vascular recanalization therapy is the major treatment strategy for acute ischemic stroke with large vessel occlusion(AIS-LVO).Time window for mechanical thrombectomy has been proven to be within 6 h after stroke onset.Screening of patients who are to undergo mechanical thrombectomy 6-24 h or beyond 24 h after onset remains controversial.In this review,we summarize the current status of mechanical thrombectomy in AIS-LVO patients with extended time window of6-24 h or beyond 24 h,and analyze the feasibility and evaluate the strategies for extending the time window of thrombectomy.

关 键 词：急性缺血性脑卒中 超时间窗 大血管闭塞 机械取栓术 

分 类 号：R743.3[医药卫生—神经病学与精神病学]