第二代抗精神病药物对精神疾病儿童体质量及代谢的影响  

Effect of Second-generation Antipsychotic Medication on Bbody Weight and Metabolism in Children with Mental Illness

作　　者：杨丹[1] 王永柏[1] 张昌[1] YANG Dan;WANG Yongbo;ZHANG Chang(Shenyang Mental Health Center,Shenyang 110168,China)

机构地区：[1]沈阳市精神卫生中心,辽宁沈阳110168

出　　处：《中国医药指南》2022年第5期73-75,共3页Guide of China Medicine

基　　金：沈阳市科学技术计划项目重点实验室专项(F16-097-1-00)。

摘　　要：目的研究第二代抗精神病药物对精神疾病儿童体质量及代谢的影响。方法选取2017年8月至2018年8月收治的40例精神疾病儿童,以随机单双号方式将患儿分为两组,两组均采取常用第二代抗精神病药物治疗,其中20例给予利培酮治疗(对照组),20例给予喹硫平治疗(研究组),比较不同抗精神病药物对患儿体质量及代谢的影响。结果两组治疗前体质量、体质量指数、体质量评分组间比较,差异无统计学意义(P>0.05);治疗后6个月、12个月,两组与治疗前相比体质量、体质量指数、体质量评分均有所增加,且增加比较明显,差异有统计学意义(P<0.05)。治疗前后两组收缩压和舒张压评分基本无明显变化,差异无统计学意义(P>0.05);治疗前,两组快速血糖、总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白等代谢指标比较,差异无统计学意义(P>0.05);治疗后6个月、12个月,两组快速血糖均显著增高,对照组低密度脂蛋白升增高明显,研究组总胆固醇增高明显,差异有统计学意义(P<0.05)。结论第二代抗精神病药物治疗精神疾病儿童会对其体质量及代谢指标产生一定影响,需要在用药治疗过程中全面评估风险,采取对应预防处理措施,避免发生其他不良事件。Objective To study the effects of second-generation antipsychotic treatment on the body weight and metabolism of children with mental illness.Methods A total of 40 children with mental illness were selected in August 2018 to August 2017.The two groups of children were divided into two groups according to the random single and double number.On behalf of antipsychotic drugs,20 patients were treated with risperidone(comparative group)and 20 patients were treated with quetiapine(study group)to compare the effects on body mass and metabolism.Results There was no statistically significant difference in body mass,body mass index,and body mass score between the two groups before treatment(P>0.05);at 6 months and 12 months after treatment,the two groups compared their body mass and body mass before treatment.The mass index and body mass score increased,and the increase was obvious,the difference was statistically significant(P<0.05);there was basically no significant change in the systolic and diastolic blood pressure scores of the two groups before and after treatment,and the difference was not statistically significant(P>0.05).Before treatment,there was no statistically significant difference between the two groups of metabolic indicators such as rapid blood glucose,total cholesterol,triacylglycerol,low-density lipoprotein,and high-density lipoprotein(P>0.05);6 months,12 months after treatment,the two groups of fast blood glucose increased significantly,the control group's low-density lipoprotein increased significantly,and the study group's total cholesterol increased significantly,the difference was statistically significant(P<0.05).Conclusion The second generation of antipsychotic drugs for children with mental illness will have certain effects on their body weight and metabolism.In the course of medication treatment,it is necessary to comprehensively assess the risk and take corresponding preventive measures to avoid other adverse events.

关 键 词：第二代抗精神病药物 利培酮 喹硫平 体质量 代谢 

分 类 号：R749[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]