氟哌啶醇与利培酮治疗痴呆患者精神行为症状的临床疗效及安全性  

Clinical Efficacy and Safety of Haloperidol and Risperidone in the Teatment of Behavioral and Psychological Symptoms of Dementia Patients

作　　者：徐莹 李艳艳 王博 XU Ying;LI Yanyan;WANG Bo(Department of Neurology,Chaoyang Central Hospital,Chaoyang,Liaoning 122000,China)

机构地区：[1]朝阳市中心医院神经内科,辽宁朝阳122000

出　　处：《中国医药指南》2022年第5期82-84,共3页Guide of China Medicine

摘　　要：目的分析氟哌啶醇与利培酮治疗痴呆患者精神行为症状(BPSD)的临床疗效以及安全性。方法选取本院接收的痴呆合并BPSD患者110例,通过等量计算机随机方法分组,各55例。A组行氟哌啶醇治疗,初始剂量为2~4 mg,分为3~4次口服,之后以患者病情为依据,逐渐将用药剂量调整为每日10~40 mg,待患者病情稳定后,将用药剂量控制在4~20 mg,治疗时间为2个月。B组行利培酮治疗,初始剂量为2 mg,口服,每日2次,之后以患者病情为依据,逐渐将用药剂量调整为每日3~5 mg,每日2次,治疗时间为2个月。两组在治疗过程中均未采取其他抗精神药物治疗,对比两组临床疗效与安全性。结果两组患者治疗前的攻击行为、行为障碍、情感障碍、焦虑、妄想评分、BEHAVED-AD总分、MMSE评分、治疗有效率比较,差异无统计学意义(P>0.05);两组患者治疗后的攻击行为、行为障碍、情感障碍、焦虑、妄想评分、BEHAVED-AD总分、MMSE评分明显优于治疗前(P<0.05),且B组患者不良反应发生率明显低于A组(P<0.05)。结论氟哌啶醇与利培酮治疗痴呆患者BPSD的临床疗效相近,但利培酮的不良反应更少,安全性更高。Objective To analyze the clinical efficacy and safety of haloperidol and risperidone in the treatment of behavioral and psychological symptoms of dementia(BPSD)in dementia patients.Methods A total of 110 patients with dementia combined with BPSD were selected and divided into 55 patients in each group by computer randomization method.Group A was treated with haloperidol with an initial dose of 2-4 mg,divided into three to four oral doses,and then gradually adjusted to 10-40 mg daily according to the patient's condition.After the patient's condition was stabilized,the dosage was controlled at 4-20 mg and the treatment lasted for 2 months.Group B received risperidone treatment,with an initial dose of 2 mg orally,twice a day,and then gradually adjusted the dose to 3-5 mg twice a day,based on the patient's condition,for 2 months.The two groups did not take other antipsychotics during the treatment process,and the clinical efficacy and safety of the two groups were compared.Results There were no significant differences in scores of aggressive behavior,behavioral disorder,affective disorder,anxiety,delusion,total score of BEHAVED-AD,MMSE score and treatment efficiency between 2 groups before and after treatment(P>0.05).After treatment,scores of aggressive behavior,behavioral disorder,affective disorder,anxiety,delusion,total score of Pour-AD and MMSE in 2 groups were significantly better than before treatment(P<0.05),while the incidence of adverse reactions in group B was significantly lower than group A(P<0.05).Conclusion Haloperidol and risperidone have similar clinical efficacy in the treatment of BPSD in dementia patients,but risperidone has fewer adverse reactions and higher safety.

关 键 词：痴呆 精神行为症状 氟哌啶醇 利培酮 安全性 

分 类 号：R749[医药卫生—神经病学与精神病学] R363.15[医药卫生—临床医学]