培土补肺汤用于非小细胞肺癌患者化疗期增效减毒作用观察  

Effective Observation on Effect-enhancing and Toxicity-reducing of Using Peitu Bufei Decoction in Non-small Cell Lung Cancer during Chemotherapy

作　　者：王群[1] 王水英[1] 王燕[1] 刘勇[1] 卞方[1] WANG Qun;WANG Shuiying;WANG Yan(Department of Oncology,Xuzhou Municipal Central Hospital,Xuzhou Jiangsu 221000,China)

机构地区：[1]徐州市中心医院肿瘤内科,江苏徐州221000

出　　处：《四川中医》2021年第12期92-95,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:研究培土补肺汤用于非小细胞肺癌患者化疗期的增效及减毒作用。方法:纳入2016年10月~2019年10月于我院收治的120例非小细胞肺癌患者为研究对象,按照随机数表法分为两组,各60例,其中对照组采取化疗方案治疗,观察组在对照组基础上给予培土补肺汤加减治疗。比较两组治疗效果,观察两组治疗前后咳嗽、咳痰、神疲乏力、纳呆症候积分变化及不良反应发生情况,分析患者1年总生存情况。结果:观察组总有效率88.33%显著高于对照组的70.00%(P<0.05)。两组治疗后咳嗽、咳痰、神疲乏力、纳呆4项症候积分均显著低于治疗前(P<0.05),观察组治疗后上述积分均显著低于对照组(P<0.05)。观察组恶心呕吐、腹痛、骨髓抑制、腹泻、肝肾功能损伤发生率均显著低于对照组(P<0.05)。患者均获有效随访1年,观察组1年累计生存率75.00%(45/60),对照组1年累计生存率58.33%(35/60),两组1年累计生存率比较差异无统计学意义(P>0.05)。结论:培土补肺汤用于非小细胞肺癌患者化疗期具有良好的增效及减毒作用,值得临床推广。Objective: To study the synergism and toxicity reduction of using Peitu Bufei Decoction in patients with non-small cell lung cancer during chemotherapy.Methods: 120 cases of non-small cell lung cancer patients in our hospital from October 2016 to October 2019 were selected as the research objects, and they were randomly divided into two groups, 60 cases in each group.The controlled group was treated with chemotherapy, and the observation group was treated with Modified Peitu Bufei Decoction on the basis of the controlled group.The treatment effects of the two groups were compared.The changes of cough, expectoration, fatigue, anorexia syndrome score and adverse reactions were observed before and after treatment, and the 1-year overall survival of the patients was analyzed.Results: The total effective rate of the observation group was 88.33%,which was significantly higher than that of the controlled group(70.00%)(P<0.05).After treatment, the scores of cough, expectoration, mental fatigue and anorexia in the two groups were significantly lower than those before treatment(P<0.05),and those in the observation group were significantly lower than those in the controlled group(P<0.05).The incidence of nausea and vomiting, abdominal pain, bone marrow suppression, diarrhea, liver and kidney function injury in the observation group were significantly lower than those in the controlled group(P<0.05).The 1-year cumulative survival rate of the observation group was 75.00%(45/60),and that of the controlled group was 58.33%(35/60).There was no significant difference in 1-year cumulative survival rate between the two groups(P>0.05).Conclusion: Peitu Bufei Decoction for non-small cell lung cancer patients in chemotherapy period has a good synergistic and toxic effect, worthy of clinical promotion.

关 键 词：培土补肺汤 非小细胞肺癌 化疗 增效减毒 

分 类 号：R734.2[医药卫生—肿瘤]