健脾清热化湿汤对脾胃湿热型慢性萎缩性胃炎患者中医症候积分、萎缩评分及PGI、PGII的影响  

Effect of Jianpi Qingre Huashi Decoction on Traditional Chinese Medicine Syndrome Score, Atrophy Score, PGI and PGII for Patients with Spleen-stomach Dampness-heat Type Chronic Atrophic Gastritis

作　　者：干晓花 袁成业[1] GAN Xiaohua;YUAN Chengye(Digestive Department,Taizhou Municipal Hospital of Traditional Chinese Medicine,Taizhou Jiangsu 225300,China)

机构地区：[1]泰州市中医院消化科,江苏泰州225300

出　　处：《四川中医》2021年第12期109-112,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：江苏省中医药科技基金项目(编号:YB2015163)。

摘　　要：目的:观察健脾清热化湿汤对脾胃湿热型慢性萎缩性胃炎(CAG)患者中医症候积分、萎缩评分及胃蛋白酶原I(PGI)、胃蛋白酶原Ⅱ(PGII)的影响。方法:选择2018年4月~2020年4月期间本院收治的脾胃湿热型CAG患者94例,按照随机数字表法,将研究对象分成2组,对照组:n=47,给予常规治疗;研究组:n=47,在对照组基础上给予健脾清热化湿汤治疗,每日1剂。12周后评价两组疗效,比较两组中医症候积分、萎缩评分,并于治疗前后检测血清PGI、PGII水平。结果:(1)研究组总有效率高于对照组(P<0.05)。(2)治疗后,两组中医症候积分均低于治疗前(P<0.05),且治疗后研究组中医症候积分低于对照组(P<0.05)。(3)治疗后,两组萎缩评估结果均低于治疗前(P<0.05),且治疗后研究组萎缩评估结果低于对照组(P<0.05)。(4)治疗后,两组血清PGI、PGII水平均高于治疗前(P<0.05),且治疗后研究组血清PGI、PGII水平高于对照组(P<0.05)。结论:健脾清热化湿汤治疗脾胃湿热型CAG疗效较好,能降低患者中医症候积分,升高血清PGI、PGII表达水平,阻止胃黏膜萎缩。Objective: To analyze the effect of Jianpi Qingre Huashi Decoction on TCM syndrome score, atrophy score, pepsinogen I(PGI) and pepsinogen II(PGII) for patients with spleen-stomach dampness-heat type chronic atrophic gastritis(CAG).Methods: A total of 94 CAG patients of spleen-stomach dampness-heat type admitted to our hospital from April 2018 to April 2020 were selected.According to the random number table method, the subjects were divided into two groups.A controlled group: n=47,given conventional treatment;a study group: n=47.On the basis of the controlled group, they were given Jianpi Qingre Huashi Decoction, 1 dose/d.The efficacy of the two groups was evaluated after 12 weeks, the TCM syndrome scores and atrophy scores of the two groups were compared, and the serum PGI and PGII levels before and after treatment were detected.Results:(1)The total effective rate of the study group was higher than that of the controlled group(P<0.05).(2) After treatment, the TCM syndrome scores of the two groups were lower than before treatment(P<0.05),and the TCM syndrome scores of the study group were lower than those of the controlled group after treatment(P<0.05).(3) After treatment, the evaluation results of atrophy in the two groups were lower than before treatment(P<0.05),and the evaluation results of atrophy in the study group after treatment were lower than those in the controlled group(P<0.05).(4) After treatment, the levels of serum PGI and PGII in the two groups were higher than those before treatment(P<0.05),and after treatment, the levels of serum PGI and PGII in the study group were higher than those in the controlled group(P<0.05).Conclusion: Jianpi Qingre Huashi Decoction is effective in treating CAG of spleen-stomach dampness-heat type.It can reduce the patients’ TCM syndrome score, increase serum PGI and PGII expression levels, and prevent gastric mucosa atrophy.

关 键 词：健脾清热化湿汤 脾胃湿热型 慢性萎缩性胃炎 中医症候积分 

分 类 号：R573.32[医药卫生—消化系统]