IgG_(4)与免疫性肝损伤疾病的关系  

Relationship between IgG_(4) and Immune Liver Injury

作　　者：宋林 王娜 SONG Lin;WANG Na(Dalian Public Health Clinical Center(Dalian Sixth People's Hospital),Dalian 116031,China)

机构地区：[1]大连市公共卫生临床中心(大连市第六人民医院),辽宁大连116000

出　　处：《中国医药指南》2022年第3期88-90,共3页Guide of China Medicine

摘　　要：目的探讨血清免疫球蛋白G_(4)(IgG_(4))与免疫性肝损伤疾病的相关性,为方便快捷做出诊断提供准确指标。方法选取2018年1月至2018年9月在本院接受治疗的不同程度肝损伤患者共计158例,根据确诊肝损伤以及疾病的不同,为患者分为3组,其中,慢性乙型肝炎组54例,原发性胆汁肝硬化组53例,自身免疫性肝炎组51例,对3组患者的血清各项生化指标进行回顾性分析,比较血清中血清免疫球蛋白G_(4)(IgG_(4))水平自身抗体差异等指标。结果慢性乙型肝炎组的静脉总胆红素(TBiL)、天冬氨酸转氨酶(AST)水平较其余两组升高较明显,但是并无统计差异(P>0.05),该组丙氨酸转氨酶(ALT)水平和其他两个组相比升高明显,差异有统计学意义(P<0.05);免疫肝炎组和肝硬化组的免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平均无明显差异,(P>0.05),其免疫球蛋白M(IgM)水平和慢性乙型肝炎组相比升高明显,有统计学差异(P<0.05),其中免疫性肝炎组的免疫球蛋白G(IgG)指标高于慢性乙型肝炎组,有统计学差异(P<0.05),免疫性肝炎组IgG_(4)比慢性乙型肝炎组和肝硬化组上升更明显(P<0.05)。免疫性肝炎组内比较,甲组抗核抗体(ANA)、抗核糖核蛋白(nRNP)、抗Ro-52抗体、抗干燥综合征抗原B(SSB)等阳性率较乙组升高明显,有统计学差异(P<0.05)。结论血清免疫球蛋白G_(4)(IgG_(4))与免疫性肝损伤疾病有一定关系,通过检测血清免疫球蛋白G_(4)(IgG_(4))水平可进一步确诊免疫性肝损伤相关疾病,检测方便快捷准确,值得推广。Objective To explore the correlation between serum immunoglobulin G_(4)(IgG_(4))and immune liver injury diseases,and to provide accurate indexes for convenient and rapid diagnosis.Methods A total of 158 patients with different degrees of liver injury treated in our hospital from January 2018 to September 2018 were selected.According to the confirmed liver injury and diseases,the patients were divided into three groups,Including 54 cases of chronic hepatitis B,53 cases of primary biliary cirrhosis and 51 cases of autoimmune hepatitis.The serum biochemical indexes of the three groups were analyzed retrospectively,the levels of serum immunoglobulin G_(4)(IgG_(4))and autoantibodies were compared.Results The levels of total bilirubin(TBiL)and ALT(ALT)in the chronic hepatitis B group were significantly higher than those in the other two groups,but there was no statistical difference(P>0.05).The levels of glutamic pyruvic transaminase(ALT)in the group were significantly higher than those in the other two groups(P<0.05).There was no significant difference in immunoglobulin G(IgG)and immunoglobulin M(IgM)levels between the immunized hepatitis group and the cirrhosis group(P>0.05),the immunoglobulin M(IgM)level increased significantly compared with the chronic hepatitis B group(P<0.05);and the immunoglobulin G(IgG)index in the immunological liver inflammation group was higher than that in the chronic hepatitis B group,with statistical difference(P<0.05).IgG_(4) in immune hepatitis group increased more significantly than that in chronic hepatitis B group and cirrhosis group(P<0.05).The positive rates of anti nuclear antibody(ANA),anti ribonucleoprotein(nRNP),anti Ro-52 antibody and anti Sjogren syndrome antigen B(SSB)in group A were higher than those in group B(P<0.05).Conclusion There is a certain relationship between serum immunoglobulin G_(4)(IgG_(4))and immune liver injury diseases.By detecting the level of serum immunoglobulin G_(4)(IgG_(4)),immune liver injury related diseases can be further diagnosed.The detection is

关 键 词：免疫性肝损伤 总胆红素 丙转氨酶 免疫球蛋白 抗干燥综合征抗原 

分 类 号：R575[医药卫生—消化系统]