胶体果胶铋联合三联用药方案治疗幽门螺杆菌感染相关胃病的临床观察  

Clinical Observation on the Treatment of Helicobacter Pylori Infection Related Gastropathy by Colloidal Bismuth Pectin Combined with Triple Drug Regimen

作　　者：邹广艳 ZOU Guangyan(Department of Gastroenterology,Benxi Railway Hospital,Benxi 117000,China)

机构地区：[1]本溪市铁路医院消化内科,辽宁本溪117000

出　　处：《中国医药指南》2022年第4期87-89,共3页Guide of China Medicine

摘　　要：目的分析幽门螺杆菌感染相关胃病特点,评价对患者采取胶体果胶铋联合三联用药方案治疗的可行性以及预后效果,以提高幽门螺杆菌感染相关胃病患者的治疗预后效果。方法选择我院2017年12月至2018年10月收治治疗的幽门螺杆菌感染相关胃病患者,选取200例。结合治疗方法,进行200例幽门螺杆菌感染相关胃病患者随机数字表法分组。参照组100例以及试验组100例。参照组患者采取三联用药常规疗法治疗,试验组患者采取胶体果胶铋联合三联用药的四联用药治疗。比较参照组与试验组幽门螺杆菌感染相关胃病患者的治疗情况,包括治疗效果、幽门螺杆菌转阴率、溃疡愈合率、随访1年复发率以及胃泌素、胃动素水平改善情况。结果试验组幽门螺杆菌感染相关胃病患者治疗总有效率95.00%、幽门螺杆菌转阴率94.00%、溃疡愈合率88.00%均明显高于参照组,P<0.05;两组患者治疗后的胃泌素、胃动素水平改善,试验组患者的改善幅度明显大于参照组,P<0.05;随访1年复发率比较,试验组复发率6.00%明显低于参照组,P<0.05。结论对比常规三联用药方案,联合胶体果胶铋后的四联用药治疗,可以进一步提高治疗效果,促进患者的症状体征改善,提高幽门螺杆菌转阴率、溃疡愈合率,资料效果确切且显著。Objective To analyze the characteristics of gastric disease related to Helicobacter pylori infection,to evaluate the feasibility and prognostic effect of the treatment of patients with colloidal bismuth pectin combined with triple therapy,so as to improve the prognostic effect of the treatment of gastric disease related to Helicobacter pylori infection.Methods We selected 200 patients with Helicobacter pylori infection-related gastric disease who were admitted to our hospital from December 2017 to October 2018.Combined with the treatment methods,200 patients with Helicobacter pylori infection-related gastric disease were randomly divided into groups.100 patients in the reference group and 100 patients in the test group.Patients in the reference group were treated with conventional triple therapy,and patients in the experimental group were treated with colloidal bismuth pectin combined with triple therapy.The treatment status of patients with gastric disease related to Helicobacter pylori infection in the reference group and the test group were compared,including the treatment effect,Helicobacter pylori conversion rate,ulcer healing rate,1 year follow-up recurrence rate,and improvement of gastrin and motilin levels.Results The total effective rate of treatment for patients with gastric diseases related to Helicobacter pylori infection in the experimental group was 95.00%,the negative conversion rate of Helicobacter pylori was 94.00%,and the healing rate of ulcers 88.00%were significantly higher than those of the reference group,P<0.05;the stomachs of the two groups of patients after treatment The levels of secretin and motilin were improved,and the improvement range of patients in the experimental group was significantly greater than that of the reference group,P<0.05;compared with the recurrence rate of 1 year follow-up,the recurrence rate of the experimental group was 6.00%significantly lower than that of the reference group,P<0.05.Conclusion Compared with the conventional triple-drug regimen,the quadruple-drug

关 键 词：胶体果胶铋 三联用药 幽门螺杆菌感染相关胃病 胃泌素 胃动素水平 

分 类 号：R573[医药卫生—消化系统]