手性卟啉的合成及其手性识别  

Synthesis and chiral recognition of chiral porphyrin

作　　者：周忠强[1] 杜瑞 ZHOU Zhongqiang;DU Rui(College of Chemistry and Materials Science,South-Central University for Nationalities,Wuhan 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2022年第1期1-7,共7页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：湖北省自然科学基金资助项目(2007ABA291)。

摘　　要：对合成的5-(4-氨基苯基)-10,15,20-三苯基卟啉进行了结构修饰,制备了L-亮氨酸衍生的手性锌卟啉(1a)和(1R,2R)-环己二胺衍生的手性锌卟啉(1b),并研究了其对α-羟基羧酸、氨基醇、二胺和二醇对映体的手性识别性能.结果表明:主体1a和1b对手性二胺有很好的手性识别作用.在低浓度下,主体1a和1b的结合常数均在10^(4)L·mol^(-1)以上,选择性识别作用非常明显,可用来定量测定手性二胺对映体混合物的组成.L-leucine-derived chiral zinc porphyrin(1a)and(1R,2R)-cyclohexanediamine-derived chiral zinc porphyrin(1b)were prepared by modification of the synthesized 5-(4-aminophenyl)-10,15,20-triphenylporphyrin,and then the chiral recognition performances for enantiomers ofα-hydroxycarboxylic acid,amino alcohol,diamine and diol were studied.The results showed they exhibited good chiral recognition effect for chiral diamine.At a low concentration,both the binding constants of hosts 1a and 1b were above 10^(4)L·mol^(-1).The obvious selective recognition effect can be used to quantitatively determine the composition of mixtures of chiral diamine enantiomers.

关 键 词：合成 手性卟啉 手性识别 

分 类 号：O621.34[理学—有机化学]