血清TNF-α、IL-6、CRP水平对老年急性脑梗死患者介入治疗后睡眠障碍的预测价值  

Value of serum TNF-α,IL-6 and CRP levels in predicting sleep disorders in elderly patients with acute cerebral infarction after interventional therapy

作　　者：武文娟[1] 邵艳敏[1] 尹小君[2] WU Wenjuan;SHAO Yanmin;YIN Xiaojun(Department of Neurology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China;Department of General Medicine,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学第一附属医院神经内科,河南洛阳471003 [2]河南科技大学第一附属医院全科医学科,河南洛阳471003

出　　处：《东南大学学报（医学版）》2021年第6期760-765,共6页Journal of Southeast University(Medical Science Edition)

基　　金：河南省医学科技攸关计划(20180200351)。

摘　　要：目的:探讨血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平对老年急性脑梗死(ACI)患者介入治疗后睡眠障碍发生风险的预测价值。方法:收集本院2017年4月至2020年8月接受介入治疗且完成6个月随访的137例老年ACI患者的临床资料,患者均接受血清TNF-α、IL-6、CRP水平检测。统计患者睡眠障碍情况并分组,分析血清TNF-α、IL-6、CRP水平与老年ACI患者介入治疗后发生睡眠障碍的关系。结果:137例老年ACI患者介入治疗后有51例发生睡眠障碍,占37.23%;睡眠障碍组TNF-α、IL-6、CRP水平均高于睡眠良好组(P<0.05);Logistic回归分析显示,血清TNF-α、IL-6、CRP过表达可能是老年ACI患者介入治疗后发生睡眠障碍的风险因子(OR>1,P<0.05);绘制ROC曲线发现,血清TNF-α、IL-6、CRP单一及联合预测老年ACI患者介入治疗后发生睡眠障碍风险的AUC均>0.80,均有一定预测价值;Spearman相关分析显示,TNF-α、IL-6、CRP三者水平均呈正相关(r>0,P<0.05)。结论:血清TNF-α、IL-6、CRP过表达与老年ACI患者介入治疗后发生睡眠障碍有关。Objective:To analyze the value of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)levels in predicting the risk of sleep disorder in elderly patients with acute cerebral infarction(ACI)after interventional therapy.Methods:The clinical data of 137 elderly ACI patients who received interventional treatment and completed 6 months of follow-up from April 2017 to August 2020 in our hospital were collected,serum TNF-α,IL-6 and CRP levels were detected.The sleep disorder patients were counted and grouped,the relationship between serum TNF-α,IL-6 and CRP levels and sleep disorders after interventional therapy in elderly ACI patients was analyzed.Results:In 137 elderly patients with ACI after interventional therapy,51 patients had sleep disorder,accounting for 37.23%;the levels of serum TNF-α,IL-6 and CRP in sleep disorder group were higher than those in the sleep well group(P<0.05);Logistic regression analysis showed that the overexpression of serum TNF-α,IL-6 and CRP alone and in combination in the elderly patients with ACI might be the risk factors of sleep disorder after interventional therapy(OR>1,P<0.05);the ROC curve was drawn,the AUC of serum TNF-α,IL-6,CRP alone and in combination in predicting the risk of sleep disorder in the elderly patients with ACI after interventional therapy were all>0.80,all had certain predictive value;Spearman correlation test showed that the levels of TNF-α,IL-6 and CRP were positively correlated(r>0,P<0.05).Conclusion:The overexpression of serum TNF-α,IL-6 and CRP in the elderly patients with ACI is related to sleep disorder after interventional therapy.

关 键 词：急性脑梗死 介入治疗 睡眠障碍 肿瘤坏死因子-Α 白细胞介素-6 C反应蛋白 预测 

分 类 号：R749.13[医药卫生—神经病学与精神病学]