弥漫大B细胞淋巴瘤中PIK3CA、PTEN的表达及临床病理学意义  

Expression of PIK3CA protein and PTEN protein in diffuse large B-cell Lymphoma and its clinicopathological significance

作　　者：马明福[1] 崔文丽[1] 王玻玮[1] 李羿兴 张巍[1] MA Mingfu;CUI Wenli;WANG Bowei;LI Yixing;ZHANG Wei(Department of Pathology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院病理科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2022年第1期44-49,共6页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金青年基金(2018D01C214)。

摘　　要：目的探讨磷脂酰肌醇-3-激酶催化亚单位α(PIK3CA)、10号染色体上缺失的磷酸酶和张力蛋白同源物(PTEN)在弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)中的表达情况及其与临床病理参数间的相关性。方法选择2010年1月1日—2013年12月31日在新疆医科大学第一附属医院病理科首次诊断的、且未接受治疗的DLBCL患者组织标本82例,运用免疫组织化学技术检测PIK3CA、PTEN的表达情况、临床病理参数及其预后相关性。结果PIK3CA、PTEN在DLBCL中阳性表达率分别为90.2%(74/82)、11.0%(9/82);病理参数研究结果显示,PIK3CA与肿瘤物直径、临床分期有关,其中肿瘤物直径≤4 cm、临床分期Ⅲ~Ⅳ期阳性率更高,差异具有统计学意义(P<0.05);PTEN蛋白质在DLBCL中的缺失率为11.0%(9/82),与其他临床病理指标未发现明显相关性(P>0.05),而PTEN表达与PIK3CA表达有关(P<0.05);生存分析结果显示,PIK3CA、PTEN与生存期之间的差异无统计学意义(P>0.05)。结论PIK3CA和PTEN表达与DLBCL的发生、发展相关,有望为DLBCL的靶向治疗提供新的理论依据。Objective To investigate the expression of PIK3CA and PTEN in diffuse large B-cell lymphoma and the correlation with clinicopathological parameters.Methods From January 2010 to December 2013,82 DLBCL tissue specimens without treatment before operation in the hospital were retrospectively analyzed.Immunohistochemical technique was used to detect the expression of PIK3CA and PTEN in all samples,and the correlation with clinicopathological indexes of prognosis was statistically analyzed.Results The positive expression rates of PIK3CA and PTEN in DLBCL were 90.2%(74/82)and 11.0%(9/82).The results of the case parameter study showed that PIK3CA was related to tumor diameter and clinical stage,and the positive rate was higher in clinical stage Ⅲ~Ⅳ with tumor diameter≤4cm.(P<0.05).PTEN was correlated with PIK3CA(P<0.05).There was no significant difference between PIK3CA and PTEN(P>0.05).Conclusion PIK3CA and PTEN played a promoting role in occurrence and development of DLBCL,which is expected to provide a new theoretical basis for DLBCL targeted therapy.

关 键 词：PIK3CA PTEN 弥漫大B细胞淋巴瘤 

分 类 号：R733.4[医药卫生—肿瘤]