Mobilization of Melanocytes During NB-UVB Treatment of Vitiligo  

作　　者：Yue Li Ru-Zhi Zhang 

机构地区：[1]Department of Dermatology,The Third Affiliated Hospital of Soochow University,Changzhou,Jiangsu 213003,China

出　　处：《International Journal of Dermatology and Venereology》2021年第3期163-167,共5页国际皮肤性病学杂志（英文）

基　　金：The authors are very grateful to Professor V.J.Hearing for help with the English-language editing.The work was supported by the National Nature Science Foundation of China(No.81673078).

摘　　要：Vitiligo,a common skin depigmentation disorder,is the result of complex interactions of genetic,immunological,environmental,and biochemical events.Treatments for vitiligo include drugs,phototherapy,surgical transplantation,and so on.Among them,the efficacy of narrow band-ultraviolet B has been confirmed.By inducing keratinocytederived factors and signalings,narrow band-ultraviolet B can trigger and/or promote the mobilization of melanocytes which migrate to lesional epidermis ultimately,leads to the repigmentation of white patches.The mobilization of melanocytes includes stages of activation,migration,proliferation,and differentiation.Elucidating processes that enable the specific mobilization of melanocytes and the signaling pathways and factors involved,will help the development of new drugs and methods for the treatment of vitiligo.

关 键 词：VITILIGO narrow band-ultraviolet B MELANOCYTE REPIGMENTATION 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]