Vitiligo is an autoimmune disorder caused by the destruction of melanocytes in various body regions.Numerous diseases may accompany vitiligo.The prevalence of vitiligo varies among geographical regions and shows no re...
funded by the CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-002);the Technology Foundation for Selected Overseas Chinese Scholar.
Notch signaling is an essential conserved mechanism through local cell interactions.It regulates cell differentiation,proliferation,and apoptotic,influencing organ formation and morphogenesis.Notch signaling plays a v...
Although perifollicular repigmentation in the vitiligo lesions is owing to activation of follicular melanocyte stem cells and/or precursor cells followed by supplying matured melanocytes, the underlying mechanism of d...
the Shenzhen Science and Technology Innovation Committee(grant numbers JCYJ20200109142444449,JCYJ20210324120007021);the National Natural Science Foundation of China(grant numbers 31801196);Basic and Applied Basic Research Foundation of Guangdong Province(grant numbers 2022A1515110645).
Norepinephrine(NA),a stress hormone,can accelerate hair graying by binding toβ2 adrenergic receptors(β_(2)AR)on melanocyte stem cells(McSCs).From this,NA-β_(2)AR axis could be a potential target for preventing the ...
This work was supported by grants from the National Key R&D Program of China(2017YFA0103500,2021YFA1101000).
Vitiligo is the most common human skin depigmenting disorder.It is mediated by endogenous autoreactive CD8+T cells that destruct skin melanocytes.This disease has an estimated prevalence of 1%of the global population ...
the National Natural Science Foundation of China(Grant No.81703140).
Vitiligo results in an autoimmune disorder destructing skin pigment cells,melanocytes(Mcs).This study aimed to investigate whether Astragaloside IV(AIV)could efficiently induce differentiation of bone marrow mesenchym...
There have been numerous therapeutic innovations in the field of dermatology during the past decade. Of these, platelet-rich plasma (PRP) has recently aroused significant interest, particularly in treating acne scars ...
supported by a grant from the National Natural Science Foundation of China(No.81972919)。
Background:There is growing evidence that 5-fluorouracil(5-FU)combined with therapeutic trauma can effectively induce skin repigmentation in vitiligo patients who are unresponsive to conventional treatments.Previous s...
The authors are very grateful to Professor V.J.Hearing for help with the English-language editing.The work was supported by the National Nature Science Foundation of China(No.81673078).
Vitiligo,a common skin depigmentation disorder,is the result of complex interactions of genetic,immunological,environmental,and biochemical events.Treatments for vitiligo include drugs,phototherapy,surgical transplant...