RHYNCHOPHYLLINE

作品数：13被引量：30H指数：3
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相关领域：医药卫生更多>>
相关作者：石京山张海龙余俊先陈修平徐瑞霞更多>>
相关机构：遵义医学院兰州大学重庆医科大学第三军医大学更多>>
相关期刊：《Natural Products and Bioprospecting》《World Journal of Integrated Traditional and Western Medicine》《Medicinal Plant》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金更多>>
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Activation of PXR causes drug interactions with Paxlovid in transgenic mice被引量：1
《Acta Pharmaceutica Sinica B》2023年第11期4502-4510,共9页Saifei Lei Alice Guo Jie Lu Qian Qi Aaron S.Devanathan Junjie Zhu Xiaochao Ma 
supported in part by the National Center for Complementary and Integrative Health (R21AT011088,USA);the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK126875,USA);the National Institute of Allergy and Infectious Diseases (R01AI131983,USA)。
Paxlovid is a nirmatrelvir(NMV)and ritonavir(RTV)co-packaged medication used for the treatment of coronavirus disease 2019(COVID-19).The active component of Paxlovid is NMV and RTV is a pharmacokinetic booster.Our wor...
关键词：Paxlovid Nirmatrelvir Ritonavir Pregnane X receptor CYP3A4/5 RIFAMPICIN RHYNCHOPHYLLINE Drug/herb-drug interactions 
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via theβ2 adrenergic pathway suppression
《Natural Products and Bioprospecting》2023年第1期14-29,共16页Xinxin Li Runlu Shi Lingchen Yan Weiwei Chu Ruishuang Sun Binkai Zheng Shuai Wang Hui Tan Xusheng Wang Ying Gao 
the Shenzhen Science and Technology Innovation Committee(grant numbers JCYJ20200109142444449,JCYJ20210324120007021);the National Natural Science Foundation of China(grant numbers 31801196);Basic and Applied Basic Research Foundation of Guangdong Province(grant numbers 2022A1515110645).
Norepinephrine(NA),a stress hormone,can accelerate hair graying by binding toβ2 adrenergic receptors(β_(2)AR)on melanocyte stem cells(McSCs).From this,NA-β_(2)AR axis could be a potential target for preventing the ...
关键词：Natural product RHYNCHOPHYLLINE STRESS Hair graying β2 adrenergic signaling 
Effect of rhynchophylline on p38MAPK/N-cadherin in zebrafish with Alzheimer disease
《中国药理学与毒理学杂志》2021年第9期660-660,共1页LIU Kai-fei WU Shi-min LI Xun-yi HUANG Yao GUAN Guo-kai CHEN Xiao-long CHEN Yi-fei 
National Natural Science Foundation of China(8216140711);Natural Sci⁃ence Foundation of Guangxi Zhuang Autono⁃mous Region(2017GXNSFAA198255);Natural Science Foundation of Guangxi Zhuang Autono⁃mous Region(2018GXNSFBA138028);Guangxi Key Laboratory of Brain and Cognitive Neurosci⁃ence Open Project Funding(GKLBCN-20180105-03);2019 College Student Innovation and Entrepreneurship Project Training Plan(201910601038);and the Fourth Training Plan for Thousands of Young and Mid-aged Mainstay Teachers in Guangxi Colleges and Universities。
OBJECTIVE To investigate the effect of rhynchophylline on zebrafish with Alzheimer disease induced by AlCl3.METHODS Zebrafish were trained in T maze for 7 d.60 zebrafish were selected and divided into 6 groups:blank g...
关键词：RHYNCHOPHYLLINE Alzheimer disease P38MAPK N-CADHERIN 
Effect of rhynchophylline on behavior of zebrafish with Alzheimer disease
《中国药理学与毒理学杂志》2021年第9期643-644,共2页LIU Kai-fei WU Shi-min LI Xun-yi HUANG Yao GUAN Guo-kai HUANG Xue-hong CHEN Yi-fei 
National Natural Science Foundation of China(8216140711);Natural Sci⁃ence Foundation of Guangxi Zhuang Autono⁃mous Region(2017GXNSFAA198255);Natural Science Foundation of Guangxi Zhuang Autono⁃mous Region(2018GXNSFBA138028);Guangxi Key Laboratory of Brain and Cognitive Neurosci⁃ence Open Project Funding(GKLBCN-20180105-03);2019 College Student Innovation and En⁃trepreneurship Project Training Plan(201910601038);and the Fourth Training Plan for Thou⁃sands of Young and Mid-aged Mainstay Teach⁃ers in Guangxi Colleges and Universities.
OBJECTIVE To investigate the effect of rhynchophylline on behavior of zebrafish with Alzheimer disease induced by AlCl3.METH⁃ODS Take a video of the zebrafish before train⁃ing,which is convenient for judging whether t...
关键词：RHYNCHOPHYLLINE Alzheimer disease ZEBRAFISH behavioral analysis 
Effects of Rhynchophylline on Learning and Memory of Alzheimer's Disease Zebrafish被引量：1
《Medicinal Plant》2021年第4期56-60,共5页Kaifei LIU Yao HUANG Guokai GUAN Shimin WU Xunyi LI Linglin CHEN Yifei CHEN 
Supported by Natural Science Foundation of Guangxi Zhuang Autonomous Area(2017GXNSFAA198255,2018GXNSFBA138028);Open Project of Guangxi Key Laboratory for Brain and Cognitive Neuroscience(GKLBCN-20180105-03);College Students'Innovation and Entrepreneurship Training Program in 2019(201910601038).The Fourth Training Plan for Thousands of Young and Mid-aged Mainstay Teachers in Guangxi Colleges and Universities.
[Objectives]To investigate the effect of rhynchophylline on the behavior of Alzheimer's disease zebrafish induced by aluminum trichloride(AlCl3),to provide theoretical basis for the development and application of rhyn...
关键词：RHYNCHOPHYLLINE Alzheimer's disease ZEBRAFISH Behavioral analysis 
Acute oral toxicity test and assessment of rhynchophylline in mice被引量：2
《Journal of Chinese Pharmaceutical Sciences》2021年第8期657-665,共9页Lanlan Hu Huijing Zhang Le Zhang Jianlin Tang 
As the main alkaloid constituent of Uncaria species,rhynchophylline has drawn extensive attention in recent years for its antihypertensive and neuroprotective activities.However,toxicity study of the rhynchophylline i...
关键词：RHYNCHOPHYLLINE Acute oral toxicity Median lethal dose MICE 
Quantification of rhynchophylline in rabbit plasma by UPLC-MS/MS and its application in a pharmacokinetic study被引量：3
《Journal of Chinese Pharmaceutical Sciences》2015年第6期393-399,共7页胡岚岚 汤建林 周世文 
It was recently revealed that Rhynchophylline （Rhy）, an important constituent of Uncaria rhynchophylla, possessed antihypertensive and neuroprotective effects. However, no information about the pharmacoldnetics of R...
关键词：RHYNCHOPHYLLINE PHARMACOKINETICS UPLC-MS/MS In rabbit 
Determination of rhynchophylline,isorhynchophylline,prim-O-glucosylcimifugin and 5-O-methylvisammioside in Babaojingfeng San by HPLC被引量：1
《World Journal of Integrated Traditional and Western Medicine》2015年第1期18-23,共6页钟鸣 刘伟锐 杨占东 卢嘉颉 蒋兆健 
National Development and Reform Commission of State Engineering Research Center for Innovation Capacity Building projects in 2011(Grant NO.:[2011]1896)
OBJECTIVE: To develop an HPLC method for the simultaneous determination of rhynchophylline, isorhynchophylline,prim-O-glucosylcimifugin and 5-O-methylvisammioside in Babaojingfeng San.METHODS: The chromatograhic separ...
关键词：Babaojingfeng San RHYNCHOPHYLLINE ISORHYNCHOPHYLLINE Prim-O-glucosylcimifugin 5-O-METHYLVISAMMIOSIDE 
Effects of rhynchophylline on monoamine transmitters of striatum and hippocampus in cerebral ischemic rats
《中国药理通讯》2004年第2期38-38,共1页LUYuan-Fu XIEXiao-Long WUQin WENGuo-Rong YANGSu-Fen SHIJing-Shan 
AIM To investigate the effects of rhynchophylline ( Rhy on monoamine transmitters and its metabolites in striatum and hippocampus of cerebral ischemic rats. METItODS The cerebral ischemic injury of rat was induced by ...
关键词：吻合口 神经传导 纹状体 海马 大脑 大鼠 动脉栓塞 
Pharmacological actions of Uncaria alkaloids,rhynchophylline and isorhynchophylline被引量：18
《Acta Pharmacologica Sinica》2003年第2期97-101,共5页石京山 余俊先 陈修平 徐瑞霞 
The pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline extracted from Uncaria rhynchophylla Miq Jacks were reviewed. The alkaloids mainly act on cardiovascular system and central nerv...
关键词：Uncaria rhynchophylla RHYNCHOPHYLLINE ISORHYNCHOPHYLLINE herbal medicine HYPERTENSION ARRHYTHMIA CALCIUM hypnotics and sedatives 
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