Pharmacological actions of Uncaria alkaloids,rhynchophylline and isorhynchophylline  

钩藤总碱、钩藤碱和异钩藤碱的药理作用

作　　者：石京山[1] 余俊先[1] 陈修平[1] 徐瑞霞[1] 

机构地区：[1]遵义医学院药理学教研室

出　　处：《Acta Pharmacologica Sinica》2003年第2期97-101,共5页中国药理学报（英文版）

摘　　要：The pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline extracted from Uncaria rhynchophylla Miq Jacks were reviewed. The alkaloids mainly act on cardiovascular system and central nervous system including the hypotension, brachycardia, antiarrhythmia, and protection of cerebral ischemia and sedation. The active mechanisms were related to blocking of calcium channel, opening of potassium channel, and regulating of nerve transmitters transport and metabolism, etc.综述了钩藤总碱、钩藤碱和异钩藤碱对心血管系统和神经系统等方面的药理作用,包括降低血压、减慢心率、抗心律失常、脑缺血保护,以及镇静等作用,其作用机制与钙通道阻滞、钾通道开放、以及神经递质转运和代谢的调节有关。

关 键 词：Uncaria rhynchophylla RHYNCHOPHYLLINE ISORHYNCHOPHYLLINE herbal medicine HYPERTENSION ARRHYTHMIA CALCIUM hypnotics and sedatives 

分 类 号：R285[医药卫生—中药学]