喘憋性肺炎婴幼儿血清维生素A、D与肺功能的相关性  

Studies on the Correlation between Serum Vitamin A,D and Lung Function in Infants with Asthmatic Pneumonia

作　　者：李琳霞[1] 李艳红[1] 吴洁[1] 张黎黎[1] 张娴[1] 王松[1] 张俊涛[1] 燕鹏 LI Linxia;LI Yanhong;WU Jie;ZHANG Lili;ZHANG Xian;WANG Song;ZHANG Juntao;YAN Peng(Dept.of Pediatrics,The 2nd Affliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院儿科,云南昆明650101

出　　处：《昆明医科大学学报》2022年第1期63-66,共4页Journal of Kunming Medical University

基　　金：云南省卫计委内设机构基金资助项目(2016NS243)。

摘　　要：目的了解喘憋性肺炎婴幼儿发作期儿童的血清25羟维生素D[25(OH)D]和维生素A水平,分析其与肺功能、血清Ig E之间的相关性,以进一步发现维生素A、D与婴幼儿喘憋性肺炎的关系。方法调查2020年1月至2021年6月昆明医科大学第二附属医院6月~3岁符合喘憋性肺炎诊断标准的56名婴幼儿和50名匹配的健康婴幼儿,用酶联免疫法检查血清25(OH)D和Ig E浓度,用肺功能仪检测喘憋性婴幼儿患者的潮气量、呼吸频率、吸气时间、达峰时间和达峰容积。分析2组儿童血清25(OH)D和维生素A含量差异,及喘憋性肺炎组患儿血清25(OH)D和维生素A水平与急性发作严重程度的相关性。结果喘憋性肺炎组患儿发作期婴幼儿血清25(OH)D和维生素A浓度分别为(18.26±6.64)ng/mL、(0.20±0.09)ng/mL显著低于对照组(25.28±3.48)ng/mL,(0.58±0.12)ng/mL,差异均有统计学意义(P<0.01)。血清25(OH)D水平与发作婴幼儿的潮气量、呼吸频率、吸气时间、达峰时间呈正相关(r=0.364、0.341、0.369和0.548),与Ig E之间呈负相关(r=-0.549)。结论喘憋性肺炎组患儿存在维生素A、D缺乏,血清维生素A、25(OH)D与喘憋性肺炎的发作存在关联。Objective To understand the serum levels of 25-hydroxyvitamin D[25(OH)D]and vitamin A in infants with asthmatic pneumonia during the onset of pneumonia,so as to analyze their correlation with lung function and serum Ig E and to further discover vitamin A and D relationship with infantile asthmatic pneumonia.Methods Fifty-six infants and 50 matched healthy infants and young children who met the diagnostic criteria for asthmatic pneumonia from June to 3 in the Second Affiliated Hospital of Kunming Medical University from 2020 to2021 were investigated,and enzyme-linked immunoassay was used to check serum 25(OH)D and Ig E concentration.A pulmonary function meter was used to detect the tidal volume、respiratory rate,Inspiratory time,up to the peak volume of infants with asthmatic infants and young children.The differences in serum 25(OH)D and vitamin A levels between the two groups of children were analyzed,and the correlation between serum 25(OH)D and vitamin A levels in children with asthmatic pneumonia and the severity of acute attacks was analyzed.Results The serum 25(OH)D and vitamin A concentrations of infants and young children in the asthmatic pneumonia group were(18.26±6.64)ng/ml and(0.20±0.09)ng/ml,respectively,which were significantly lower than those of the control group(25.28±3.48)ng/ml,(0.58±0.12)ng/ml,the difference was statistically significant(P<0.01).Serum 25(OH)D levels were positively correlated with the tidal volume,respiratory rate,Inspiratory time,up to the peak volume in infants with onset(r=0.364,0.341,0.369 and 0.548),and negatively correlated with Ig E(r=-0.549).Conclusion Children in the asthmatic pneumonia group had vitamin A and D deficiency,and serum vitamin A,25(OH)D asthmatic pneumonia episodes were associated.

关 键 词：喘憋性肺炎 婴幼儿 维生素A 维生素D 肺功能 

分 类 号：R723[医药卫生—儿科]