黄芪注射液对急性胰腺炎患者氧化应激状态及肠黏膜屏障功能的影响  

Effects of Huangqi Injection on the oxidative stress and intestinal mucosal barrier function in patients with acute pancreatitis

作　　者：张琪[1] 张会芳[1] 李兆洋 曹玉萍[1] 张国彦[1] 郑洋 ZHANG Qi;ZHANG Huifang;LI Zhaoyang;CAO Yuping;ZHANG Guoyan;ZHENG Yang(The First Central Hospital of Baoding City,Baoding 071000,China;The First People’s Hospital of Xingtai City,Xingtai 054000,China)

机构地区：[1]保定市第一中心医院,河北保定071000 [2]邢台市第一人民医院,河北邢台054000

出　　处：《吉林中医药》2021年第12期1616-1619,共4页Jilin Journal of Chinese Medicine

基　　金：河北省邢台市科技计划项目(2016ZC274)。

摘　　要：目的探讨黄芪注射液对急性胰腺炎患者氧化应激状态及肠黏膜屏障功能的影响。方法采用随机数表法将90例急性胰腺炎患者随机分观察组和对照组,各45例。对照组给予西医内科常规处理,观察组在对照组治疗基础上给予黄芪注射液治疗,2组均治10 d。观察2组治疗前后急性生理和慢性健康状况评分(APACHEⅡ)、急性胰腺炎严重程度床边指数评分(BISAP)、血清氧化应激指标及肠黏膜屏障功能指标的改善状况,比较2组临床疗效、症状缓解时间及药物安全性。结果观察组治疗后总有效率95.6%,高于对照组的80.0%(P<0.05);与治疗前比较,2组治疗后APACHEⅡ评分和BISAP评分下降(P<0.05),血清SOD水平上升(P<0.05),血清MDA、内毒素、D-乳酸水平下降(P<0.05),且观察组均优于对照组(P<0.05)。观察组腹痛消失时间、腹胀消失时间及肠鸣音恢复时间均优于对照组(P<0.05),结论黄芪注射液能够改善急性胰腺炎患者体内氧化应激反应,保护肠黏膜屏障功能,对疾病的预后转归具有明显的促进作用。Objective To investigate the effects of Huangqi Injection on the oxidative stress and intestinal mucosal barrier function in patients with acute pancreatitis.Methods A total of 90 patients with acute pancreatitis were randomly divided into an observation group and a control group,with 45 cases in each group.The control group was treated with a conventional western medicine,while the observation group was treated with Huangqi Injection on the basis of the control group,both for 10 days.The improvement of the acute physiology and chronic health evaluation(APACHE Ⅱ)score,bedside index for severity in acute pancreatitis(BISAP)score,serum oxidative stress index and intestinal mucosal barrier function index were observed before and after treatment in the two groups,and the clinical efficacy,symptom relief time and drug safety were compared between the two groups.Results The total effective rate of the observation group was 95.6%after treatment,higher than 80.0%of the control group(P<0.05).After treatment,the APACHE Ⅱ score and BISAP score of the two groups were decreased(P<0.05),while the serum SOD level was increased(P<0.05),and the serum MDA,endotoxin and D-lactic acid levels were decreased(P<0.05),and the observation group was better than the control group(P<0.05).The disappearance time of abdominal pain,abdominal distension and the recovery time of bowel sounds in the observation group were better than those in the control group(P<0.05).Conclusion Huangqi Injection can improve the oxidative stress response in patients with acute pancreatitis,protect the intestinal mucosal barrier function,and significantly promote the prognosis and outcome of the disease.

关 键 词：黄芪注射液 急性胰腺炎 氧化应激状态 肠黏膜屏障功能 

分 类 号：R576[医药卫生—消化系统]