血清DKK1、TK1水平预测老年胸段食管癌患者根治术后复发、转移的研究  

Research on serum DKK1 and TK1 levels in predicting recurrence and metastasis after radical resection in elderly patients with thoracic esophageal cancer

作　　者：陈婷[1] 秦永辉[1] 刘凯[1] CHEN Ting;QIN Yonghui;LIU Kai(Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院,新疆乌鲁木齐830011

出　　处：《国际检验医学杂志》2022年第2期239-243,共5页International Journal of Laboratory Medicine

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2020-13);新疆维吾尔自治区自然科学基金项目(2020D01C203)。

摘　　要：目的分析血清分泌型蛋白Dikkopf1(DKK1)、细胞质胸苷激酶1(TK1)水平与老年胸段食管癌患者根治术后复发、转移的关系。方法选取2016年6月至2018年6月于该院接受根治术治疗的63例老年胸段食管癌患者为研究对象,全部患者术后均接受为期3年的随访,依据随访期间复发、转移的发生情况分为发生组与未发生组,比较两组一般资料、实验室检测结果,分析根治术前血清DKK1、TK1水平与患者术后复发、转移的关系。结果63例老年胸段食管癌患者发生复发、转移26例,发生率为41.27%;发生组术前血清癌胚抗原(CEA)、鳞状细胞癌抗原(SCC)、DKK1、TK1水平均高于未发生组(P<0.05);相关性分析结果显示,老年胸段食管癌患者血清CEA、SCC、DKK1及TK1之间呈正相关(P<0.05);Logistic回归分析结果显示,老年胸段食管癌患者根治术前血清CEA、SCC、DKK1、TK1异常表达与术后复发、转移有关,各指标异常表达可能是老年胸段食管癌患者术后复发、转移的危险因素(OR>1,P<0.05);绘制受试者工作特征曲线,结果显示,老年胸段食管癌患者根治术前血清CEA、SCC、DKK1、TK1水平预测术后复发、转移风险的曲线下面积均>0.800,预测价值较理想,且根治术前血清DKK1、TK1的最佳截断值分别为3.535 ng/mL、3.470 pmol/L时,预测价值最佳。结论老年胸段食管癌患者根治术前血清DKK1、TK1水平与术后复发、转移有关,二者异常表达可能是患者根治术后复发、转移的危险因素,将二者用于预测患者根治术后的复发、转移风险有一定价值。Objective To analyze the relationship between the expressions of serum secretory protein Dikkopf1(DKK1)and cytosolic thymidine kinase 1(TK1)with the recurrence and metastasis after radical resection in elderly patients with thoracic esophageal carcinoma.Methods A total of 63 elderly patients with thoracic esophageal cancer receiving the radical resection in this hospital from June 2016 to December 2018 were selected and followed up for postoperative 3 years,according to the occurrence of recurrence and metastasis during the follow-up period,they were divided into the occurrence group and non-occurrence group.The general data and laboratory detection results were compared between the two groups,then the relationship between serum DKK1 and TK1 levels before radical resection with postoperative recurrence and metastasis was analyzed.Results Among 63 elderly cases of thoracic esophageal cancer,26 cases had recurrence and metastasis with the incidence rate of 41.27%.The preoperative levels of serum carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC),DKK1 and TK1 in the occurrence group were higher than those in the non-occurrence group(P<0.05).The results of correlation analysis showed that the positive correlation existed in serum CEA,SCC,DKK1 and TK1 levels of elderly patients with thoracic esophageal cancer(P<0.05).The Logistic regression analysis results showed that the abnormal expression levels of serum CEA,SCC,DKK1 and TK1 before radical resection were correlated with postoperative recurrence and metastasis in elderly patients with thoracic esophageal cancer,the abnormal expressions of various indexes might be the risk factors for postoperative recurrence and metastasis in elderly patients with thoracic esophageal cancer(OR>1,P<0.05).The receiver operating characteristic(ROC)curve was drawn,and the results showed that the area under the curve(AUC)of preoperative serum CEA,SCC,DKK1 and TK1 levels in predicting the risk of recurrence and metastasis in elderly patients with thoracic esophageal cance

关 键 词：食管癌 根治术 复发 转移 分泌型蛋白Dikkopf1 细胞质胸苷激酶1 

分 类 号：R735.1[医药卫生—肿瘤]